Annandale is a strath in Dumfries and Galloway, Scotland, named after the dale of the River Annan. It runs north–south through the Southern Uplands from Annanhead to Annan on the Solway Firth, and in its higher reaches it separates the Moffat hills on the east from the Lowther hills to the west. A 53-mile (85 km) long-distance walking route called Annandale Way running through Annandale was opened in September 2009.