Two-time defending champion Novak Djokovic defeated Matteo Berrettini in the final, 6–7(4–7), 6–4, 6–4, 6–3 to win the gentlemen's singles tennis title at the 2021 Wimbledon Championships. It was his sixth Wimbledon title and record-equaling 20th major men's singles title overall, tying Roger Federer and Rafael Nadal's all-time record total.