English Pronunciation Audio (General Australian):(file) Phrase what's with (colloquial, sometimes rhetorical question) What is wrong with. What's with Jim lately? He always has a frown on his face. (colloquial, sometimes rhetorical question) What is the reason for. What's with all the presents? Are you having a birthday party? See also what's up with what gives what's cooking Wikiwand - on Seamless Wikipedia browsing. On steroids.