English Etymology 1 Blend of lesbian + yuppie Noun luppie (plural luppies) A high-earning gay woman living in a major urban area. 2000, Bell Hooks, Where we stand: class matters, page 138:A luppie (lesbian professional) doesn't need to harm or displace a fly Related terms guppie Etymology 2 Blend of Latino + yuppie Noun luppie (plural luppies) (rare) A high-earning Latino living in a major urban area. References Slang: The Topical Dictionary of Americanisms Anagrams pile up, pile-up, pileup, uppileWikiwand - on Seamless Wikipedia browsing. On steroids.