See also: spice, SPICE, spíce, and špice Proper noun Spice (plural Spices) A surname. Statistics According to the 2010 United States Census, Spice is the 28333rd most common surname in the United States, belonging to 843 individuals. Spice is most common among White (87.9%) individuals. Anagrams SPECI, pices, epics, sepic, Epics