English Noun LPN (plural LPNs) Initialism of licensed practical nurse. 2016, Yaa Gyasi, Homegoing, Penguin Books (2017), page 280:Marjorie had heard the other LPNs at the nursing home where Esther worked talk like this. (networking) Initialism of Low-Power Network. Synonyms (networking): LPWAN Related terms RN References LPN on Wikipedia.Wikipedia Anagrams L/NP, LNP, NLP, NPL, PNLWikiwand - on Seamless Wikipedia browsing. On steroids.