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Desvenlafaxine
Medication used to treat major depressive disorder / From Wikipedia, the free encyclopedia
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Desvenlafaxine, sold under the brand name Pristiq among others, is a medication used to treat depression.[5] It is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class and is taken by mouth.[5] It is recommended that the need for further treatment be occasionally reassessed.[5] It may be less effective than its parent compound venlafaxine,[6] although some studies have found comparable efficacy.[7]
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Trade names | Pristiq, Desfax, Ellefore, others |
Other names | O-desmethylvenlafaxine, WY-45233 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a608022 |
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Routes of administration | By mouth |
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Bioavailability | 80% |
Protein binding | Low (30%) |
Metabolism | CYP2C19,[4] CYP3A4, (CYP2D6 is not involved) |
Elimination half-life | 11 h |
Excretion | 45% excreted unchanged in urine |
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ECHA InfoCard | 100.149.615 ![]() |
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Formula | C16H25NO2 |
Molar mass | 263.381 g·mol−1 |
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Common side effects include dizziness, trouble sleeping, increased sweating, constipation, sleepiness, anxiety, and sexual problems.[5] Serious side effects may include suicide in those under the age of 25, serotonin syndrome, bleeding, mania, and high blood pressure.[5] A withdrawal syndrome may occur if the dose is decreased or the medication is completely stopped.[5] It is unclear if use during pregnancy or breastfeeding is safe.[8]
Desvenlafaxine was approved for medical use in the United States in 2008.[5] In Europe its application for use was denied in 2009,[6] but it is available in Spain and Germany.[citation needed] In 2021, it was the 178th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[9][10]