Chlorambucil
Chemical compound / From Wikipedia, the free encyclopedia
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Chlorambucil, sold under the brand name Leukeran among others, is a chemotherapy medication used to treat chronic lymphocytic leukemia (CLL), Hodgkin lymphoma, and non-Hodgkin lymphoma.[2] For CLL it is a preferred treatment.[3] It is given by mouth.[3]
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Trade names | Leukeran, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682899 |
Routes of administration | By mouth |
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Bioavailability | ? |
Metabolism | Liver |
Elimination half-life | 1.5 hours |
Excretion | N/A |
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ECHA InfoCard | 100.005.603 |
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Formula | C14H19Cl2NO2 |
Molar mass | 304.21 g·mol−1 |
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Common side effects include bone marrow suppression.[3] Other serious side effects include an increased long term risk of further cancer, infertility, and allergic reactions.[3] Use during pregnancy often results in harm to the baby.[3] Chlorambucil is in the alkylating agent family of medications.[3] It works by blocking the formation of DNA and RNA.[3]
Chlorambucil was approved for medical use in the United States in 1957.[3] It is on the World Health Organization's List of Essential Medicines.[4][5] It was originally made from nitrogen mustard.[3]