Wyllie is a surname. Notable people with the surname include:
- Adrian Wyllie (born 1970), American political activist, radio personality, and investigative journalist
- Alex Wyllie (born 1944), New Zealand rugby union player and coach
- Andrew Wyllie (pathologist), Scottish pathologist
- Bill Wyllie (c.1932–2006), Australian businessman
- Bob Wyllie (1929–1981), Scottish footballer
- Curzon Wyllie (1848–1909), Indian army officer
- Daniel Wyllie (born 1970), American actor
- Douglas Wyllie (born 1963), Scottish rugby player and coach
- Edward Wyllie (1848–1911), American medium
- George Wyllie (1921–2012), Scottish artist
- George Wyllie (GC) (1908–1987), British Army soldier and recipient of the George Cross
- Hamish Daud Wyllie (born 1980), Indonesian actor
- Hugh Wyllie (born 1934), Moderator of the Church of Scotland
- James Wyllie (1818–1899), Scottish draughts player
- Kate Wyllie (1840s−1913), New Zealand tribal leader
- Meg Wyllie (1917–2002), American actress
- Peter John Wyllie (born 1930), British petrologist and academic
- Robert Crichton Wyllie (1798–1865), Scottish physician and businessman
- Ross D. Wyllie (born 1944), Australian singer and television presenter
- Thomas Wyllie (1872–1943), Scottish football player
- Tony Wyllie (born 1967), American NFL executive
- Tu Wyllie (born 1954), New Zealand politician and rugby player
- William Wyllie (disambiguation)