William Sutherland may refer to:
- William Sutherland of Roscommon (died 1715), Member of the Scottish Parliament
- William Sutherland, 17th Earl of Sutherland (1708–1750), Scottish nobleman
- William Sutherland (British Army officer), fought in the American Revolutionary War
- William Sutherland (Northwest Territories politician) (1854–1930), general merchant and political figure in the Northwest Territories, Canada
- William Sutherland (physicist) (1859–1911), Australian physicist
- William Charles Sutherland (1865–1940), Speaker of the Legislative Assembly of Saskatchewan, Canada
- William Garner Sutherland (1873–1954), American osteopath
- William A. Sutherland (California politician) (1874–1935), American lawyer and California State Assemblyman
- William Andrew Sutherland (1849–1908), New York lawyer and politician
- William A. Sutherland (American football) (1876–1969), American football coach and lawyer
- William Henry Sutherland (1876–1945), physician and political figure in British Columbia
- Sir William Sutherland (Liberal politician) (1880–1949), Chancellor of the Duchy of Lancaster
- William Sutherland (Ontario politician) (1926/7–1998), city councillor in North York, Ontario
- Sir William Sutherland (police officer) (1933–2022), British police officer
- Bill Sutherland (1934–2017), Canadian ice hockey player
- William R. Sutherland, better known as Bert Sutherland (1936–2020), American technology researcher
- T. Bill Sutherland (born 1942), American theoretical physicist
- William J. Sutherland (born 1956), British conservation biologist