Proto-oncogene Wnt-1

Proto-oncogene Wnt-1, or Proto-oncogene Int-1 homolog is a protein that in humans is encoded by the WNT1 (INT1) gene.^[5][6]

WNT1
Identifiers
Aliases	WNT1, BMND16, INT1, OI15, Wnt family member 1
External IDs	OMIM: 164820; MGI: 98953; HomoloGene: 3963; GeneCards: WNT1; OMA:WNT1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 48,978,322 bp[1] End 48,982,620 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F1|15 54.65 cM Start 98,687,738 bp[2] End 98,691,718 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte nucleus accumbens superior frontal gyrus right frontal lobe prefrontal cortex putamen blood caudate nucleus bone marrow Brodmann area 9 Top expressed in muscle layer of urethra pelvic part of vagina rhombic lip ejaculatory duct perineal part of vagina inner cell mass epithelium of seminiferous tubule of testis choroid plexus of fourth ventricle female urethra morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity protein domain specific binding frizzled binding morphogen activity signaling receptor binding receptor ligand activity Cellular component cytoplasm endocytic vesicle membrane endoplasmic reticulum lumen plasma membrane extracellular region cell surface Golgi lumen extracellular exosome extracellular space Biological process negative regulation of cell-substrate adhesion forebrain anterior/posterior pattern specification dopaminergic neuron differentiation neurogenesis cell fate commitment negative regulation of fat cell differentiation positive regulation of protein phosphorylation myotube differentiation metencephalon development midbrain-hindbrain boundary maturation during brain development T cell differentiation in thymus spinal cord association neuron differentiation negative regulation of cell-cell adhesion neuron fate determination signal transduction in response to DNA damage central nervous system morphogenesis positive regulation of fibroblast proliferation positive regulation of dermatome development cell-cell signaling negative regulation of cell differentiation hematopoietic stem cell proliferation cell proliferation in midbrain positive regulation of DNA-binding transcription factor activity embryonic axis specification hepatocyte differentiation negative regulation of transforming growth factor beta receptor signaling pathway cerebellum development ubiquitin-dependent SMAD protein catabolic process cerebellum formation negative regulation of BMP signaling pathway canonical Wnt signaling pathway involved in negative regulation of apoptotic process positive regulation of transcription, DNA-templated multicellular organism development diencephalon development branching involved in ureteric bud morphogenesis cellular response to peptide hormone stimulus midbrain-hindbrain boundary development embryonic brain development response to wounding positive regulation of insulin-like growth factor receptor signaling pathway inner ear morphogenesis animal organ regeneration positive regulation of cell population proliferation negative regulation of ubiquitin-dependent protein catabolic process neuron fate commitment myoblast fusion positive regulation of lamellipodium assembly bone development Spemann organizer formation midbrain development positive regulation of Notch signaling pathway positive regulation of transcription by RNA polymerase II Wnt signaling pathway astrocyte-dopaminergic neuron signaling positive regulation of canonical Wnt signaling pathway Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Wnt signaling pathway, planar cell polarity pathway beta-catenin destruction complex disassembly negative regulation of oxidative stress-induced neuron death regulation of signaling receptor activity canonical Wnt signaling pathway negative regulation of apoptotic process neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7471 22408 Ensembl ENSG00000125084 ENSMUSG00000022997 UniProt P04628 P04426 RefSeq (mRNA) NM_005430 NM_021279 RefSeq (protein) NP_005421 NP_067254 Location (UCSC) Chr 12: 48.98 – 48.98 Mb Chr 15: 98.69 – 98.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.^[7]

See also

• Wnt signaling pathway

References

1. GRCh38: Ensembl release 89: ENSG00000125084 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022997 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. van Ooyen A, Kwee V, Nusse R (Jan 1986). "The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences". EMBO J. 4 (11): 2905–9. doi:10.1002/j.1460-2075.1985.tb04021.x. PMC 554596. PMID 2998762.
6. Arheden K, Mandahl N, Strombeck B, Isaksson M, Mitelman F (May 1988). "Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization". Cytogenet Cell Genet. 47 (1–2): 86–87. doi:10.1159/000132513. PMID 3281802.
7. "Entrez Gene: WNT1 wingless-type MMTV integration site family, member 1".

Further reading

• McMahon AP, Moon RT (1990). "int-1--a proto-oncogene involved in cell signalling". Development. 107 Suppl: 161–7. doi:10.1242/dev.107.Supplement.161. PMID 2534596.
• Chance PF, Cavalier L, Satran D, Pellegrino JE, Koenig M, Dobyns WB (1999). "Clinical nosologic and genetic aspects of Joubert and related syndromes". J. Child Neurol. 14 (10): 660–666. doi:10.1177/088307389901401007. PMID 10511339. S2CID 38298436.
• De Ferrari GV, Moon RT (2007). "The ups and downs of Wnt signaling in prevalent neurological disorders". Oncogene. 25 (57): 7545–7553. doi:10.1038/sj.onc.1210064. PMID 17143299. S2CID 35684619.
• Thomas KR, Capecchi MR (1990). "Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development". Nature. 346 (6287): 847–850. Bibcode:1990Natur.346..847T. doi:10.1038/346847a0. PMID 2202907. S2CID 4341682.
• Turc-Carel C, Pietrzak E, Kakati S, Kinniburgh AJ, Sandberg AA (1988). "The human int-1 gene is located at chromosome region 12q12-12q13 and is not rearranged in myxoid liposarcoma with t(12;16) (q13;p11)". Oncogene Res. 1 (4): 397–405. PMID 3329717.
• Wang YK, Samos CH, Peoples R, Pérez-Jurado LA, Nusse R, Francke U (1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Hum. Mol. Genet. 6 (3): 465–472. doi:10.1093/hmg/6.3.465. PMID 9147651.
• Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA (1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". J. Biol. Chem. 274 (23): 16180–16187. doi:10.1074/jbc.274.23.16180. PMID 10347172.
• Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, Aaronson SA (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene. 18 (44): 5959–5966. doi:10.1038/sj.onc.1202985. PMID 10557084. S2CID 2009505.
• Lee CS, Buttitta LA, May NR, Kispert A, Fan CM (2000). "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm". Development. 127 (1): 109–18. doi:10.1242/dev.127.1.109. PMID 10654605.
• Tanaka K, Okabayashi K, Asashima M, Perrimon N, Kadowaki T (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". Eur. J. Biochem. 267 (13): 4300–4311. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835.
• Tamai K, Semenov M, Kato Y, Kato Y, Spokony R, Liu C, Katsuyama Y, Hess F, Saint-Jeannet JP (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature. 407 (6803): 530–535. Bibcode:2000Natur.407..530T. doi:10.1038/35035117. PMID 11029007. S2CID 4400159.
• Mao J, Wang J, Liu B, Pan W, Farr GH, Flynn C, Yuan H, Takada S, Kimelman D (2001). "Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway". Mol. Cell. 7 (4): 801–809. doi:10.1016/S1097-2765(01)00224-6. PMID 11336703.
• Kirikoshi H, Sekihara H, Katoh M (2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID 11350055.
• Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. 11 (12): 951–961. Bibcode:2001CBio...11..951S. doi:10.1016/S0960-9822(01)00290-1. PMID 11448771. S2CID 15702819.
• Mizushima T, Nakagawa H, Kamberov YG, Wilder EL, Klein PS, Rustgi AK (2002). "Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells". Cancer Res. 62 (1): 277–82. PMID 11782388.
• Tice DA, Szeto W, Soloviev I, Rubinfeld B, Fong SE, Dugger DL, Winer J, Williams PM, Wieand D (2002). "Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling". J. Biol. Chem. 277 (16): 14329–14335. doi:10.1074/jbc.M200334200. PMID 11832495.