Tobramycin/dexamethasone, sold under the brand name Tobradex, is a fixed-dose combination medication in the form of eye drops and eye ointment, marketed by Alcon.[1][2][3] The active ingredients are tobramycin (an antibiotic) and dexamethasone (a corticosteroid).[2] It is prescribed for the treatment of pink eye in combination with bacterial infections.[2]

Quick Facts Combination of, Dexamethasone ...
Tobramycin/dexamethasone
Combination of
TobramycinAminoglycoside antibiotic
DexamethasoneGlucocorticoid
Clinical data
Trade namesTobradex
AHFS/Drugs.comProfessional Drug Facts
Routes of
administration
Eye drops, topical
ATC code
Legal status
Legal status
Identifiers
CAS Number
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
 ☒NcheckY (what is this?)  (verify)
Close

Contraindications

It is contraindicated with herpetic and other viral eye infections. Other contraindications include fungal and mycobacterial infections because tobramycin is inactive against those, and the corticoid acts as an immunosuppressive agent, preventing the body's immune system from dealing with the infection. The drops are also contraindicated in patients with corneal lesions.[4][1][2][3]

Side effects

Similarly to other corticosteroid eye drops, side effects include hypersensitivity and, especially after long-term use, secondary eye infections, cataract (clouding of the eye lens) and increased intraocular pressure, leading to glaucoma. Consequently, the drug should not be applied longer than 24 days[4][5][6] without further medical evaluation.[2][3]

Interactions

Anticholinergic eye drops potentiate the risk of increased intraocular pressure. Systemic aminoglycoside antibiotics increase toxicity for ears, nerves and kidney.[4]

Brand names

Tobrason is a brand name in Jordan.[7][failed verification]

References

Wikiwand in your browser!

Seamless Wikipedia browsing. On steroids.

Every time you click a link to Wikipedia, Wiktionary or Wikiquote in your browser's search results, it will show the modern Wikiwand interface.

Wikiwand extension is a five stars, simple, with minimum permission required to keep your browsing private, safe and transparent.