Calcium carbimide

Calcium carbimide, sold as the citrate salt under the trade name Temposil, is a disulfiram-like medication. Its effects are similar to the medication disulfiram (Antabuse) in that it interferes with the normal metabolism of alcohol by preventing the breakdown of the metabolic byproduct acetaldehyde. The result is that when alcohol is consumed by users of calcium carbimide, they experience severe reactions which include symptoms such as sweating, difficulty breathing, rapid heartbeat, rash, nausea and vomiting, and headache.

Calcium carbimide

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N07BB02 (WHO)
Identifiers
IUPAC name calcium 2-hydroxypropane-1,2,3-tricarboxylate; methylcyanamide
CAS Number	156-62-7 Y citrated: 8013-88-5 Y
PubChem CID	6335910
ChemSpider	21106422 Y
UNII	ZLR270912W citrated: 21ZCD2AA4H Y
ChEMBL	ChEMBL2106095 N
Chemical and physical data
Formula	C6H6O7.C2H4N2.Ca
3D model (JSmol)	Interactive image
SMILES [Ca+2].O=C([O-])CC(O)(CC(=O)O)C([O-])=O.N#CNC
InChI InChI=1S/C6H8O7.C2H4N2.Ca/c7-3(8)1-6(13,5(11)12)2-4(9)10;1-4-2-3;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);4H,1H3;/q;;+2/p-2 Y Key:ZZOBQLACMMNMCT-UHFFFAOYSA-L Y
NY (what is this?)  (verify)

A recent 9-year study found that incorporation of supervised carbimide and the similar medication, disulfiram, into a comprehensive treatment program resulted in an abstinence rate of over 50%.^[1]

Temposil was developed by Drs. Ken Ferguson and Gordon Bell, who tested the medication on themselves.^[2][3][4] It was patented in 1955 by the Alcoholism Research Foundation of Ontario.^[5]

See also

• Acamprosate
• Disulfiram-alcohol reaction

References

1. Krampe H, Stawicki S, Wagner T, et al. (January 2006). "Follow-up of 180 alcoholic patients for up to 7 years after outpatient treatment: impact of alcohol deterrents on outcome". Alcoholism: Clinical and Experimental Research. 30 (1): 86–95. doi:10.1111/j.1530-0277.2006.00013.x. ISSN 0145-6008. PMID 16433735.
2. "Ogspi "PLO" 2005 Obituary". Ontario Genealogical Society. Archived from the original on 2015-09-24. Retrieved 2014-03-11.
3. "Deaths - Canadian Medical Association Journal". CMAJ. 162 (8). Canadian Medical Association Journal: 1259. 18 April 2000.
4. "Pioneer in Addiction Treatment Dr. Robert Gordon Bell Leaves Behind a Legacy of Hope and Healing" (PDF). Ontario Federation of Community Mental Health and Addiction Programs. Archived from the original (PDF) on 2014-03-11.
5. Booze: A Distilled History. Between The Lines. 2003. ISBN 9781896357836.