MAP3K7IP3

Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 is an enzyme that in humans is encoded by the MAP3K7IP3 gene.^[5][6][7]

TAB3
Identifiers
Aliases	TAB3, MAP3K7IP3, NAP1, TGF-beta activated kinase 1/MAP3K7 binding protein 3, TGF-beta activated kinase 1 and MAP3K7 binding protein 3, TGF-beta activated kinase 1 (MAP3K7) binding protein 3
External IDs	OMIM: 300480; MGI: 1913974; HomoloGene: 17673; GeneCards: TAB3; OMA:TAB3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp21.2 Start 30,827,442 bp[1] End 30,975,084 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X C1 Start 85,574,022 bp[2] End 85,634,469 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic epithelial cell pancreatic ductal cell germinal epithelium amniotic fluid epithelium of nasopharynx buccal mucosa cell gingival epithelium tail of epididymis palpebral conjunctiva visceral pleura Top expressed in retinal pigment epithelium ureter facial motor nucleus primitive streak medullary collecting duct blood hair follicle Paneth cell fetal liver hematopoietic progenitor cell sexually immature organism More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding protein binding Cellular component cytosol plasma membrane endosome membrane extracellular exosome Biological process stimulatory C-type lectin receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway Fc-epsilon receptor signaling pathway JNK cascade positive regulation of NF-kappaB transcription factor activity I-kappaB kinase/NF-kappaB signaling negative regulation of autophagy nucleotide-binding oligomerization domain containing signaling pathway MyD88-independent toll-like receptor signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling interleukin-1-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 257397 66724 Ensembl ENSG00000157625 ENSMUSG00000035476 UniProt Q8N5C8 Q571K4 RefSeq (mRNA) NM_152787 NM_198312 NM_001399870 NM_001399872 NM_001399873 NM_025729 NM_001358447 RefSeq (protein) NP_690000 NP_080005 NP_001345376 Location (UCSC) Chr X: 30.83 – 30.98 Mb Chr X: 85.57 – 85.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[7]

Interactions

MAP3K7IP3 has been shown to interact with MAP3K7IP2,^[5] TAB1^[6] and MAP3K7.^[5][6]

References

1. GRCh38: Ensembl release 89: ENSG00000157625 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035476 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (Nov 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J. 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMC 291846. PMID 14633987.
6. Cheung PC, Nebreda AR, Cohen P (Feb 2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075.
7. "Entrez Gene: MAP3K7IP3 mitogen-activated protein kinase kinase kinase 7 interacting protein 3".

Further reading

• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Jin G, Klika A, Callahan M, Faga B, Danzig J, Jiang Z, Li X, Stark GR, Harrington J, Sherf B (2004). "Identification of a human NF-kappaB-activating protein, TAB3". Proc. Natl. Acad. Sci. U.S.A. 101 (7): 2028–33. Bibcode:2004PNAS..101.2028J. doi:10.1073/pnas.0307314101. PMC 357046. PMID 14766965.
• Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ (2004). "TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains". Mol. Cell. 15 (4): 535–48. doi:10.1016/j.molcel.2004.08.008. PMID 15327770.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Besse A, Lamothe B, Campos AD, Webster WK, Maddineni U, Lin SC, Wu H, Darnay BG (2007). "TAK1-dependent signaling requires functional interaction with TAB2/TAB3". J. Biol. Chem. 282 (6): 3918–28. doi:10.1074/jbc.M608867200. PMC 3197015. PMID 17158449.