Saint Dominic or Dominic de Guzmán was the Roman Catholic founder of the order of Dominicans.
St Dominic or Saint Dominic may also refer to:
United States
- St. Dominic Regional High School, Auburn, Maine
- Saint-Dominic Academy, a Catholic grammar school and high school in Lewiston and Auburn, Maine
- St Dominic High School (O'Fallon, Missouri)
- Mount Saint Dominic Academy, a Catholic high school for women in Caldwell, New Jersey
- St Dominic High School (Oyster Bay, New York)
- St Agnes Academy-St Dominic School, Memphis, Tennessee
- St Dominic Savio Catholic High School, North Austin, Texas
- Domenico
- San Domenico (disambiguation)
- Domingo (disambiguation)
- Santo Domingo, the capital city of the Dominican Republic, formerly the Spanish Captaincy General of Santo Domingo of Hispaniola
- Abbey of Santo Domingo de Silos, Santo Domingo de Silos, Burgos, Spain
- Santo Domingo Church, Quezon City, Philippines
- Domingue (disambiguation)
- Saint-Domingue, a former French colony of Hispaniola and the modern-day Republic of Haiti
- Dominic (disambiguation)
- Dominic
- Dominica or the Commonwealth of Dominica, an island country in the Lesser Antilles
- Santo Domingo (disambiguation)
- St. Dominic High School (disambiguation)
- Saint Dominic's Preview, an album by Van Morrison
- Domino (comics)