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- Adam Sinclair (field hockey), hockey player
- Adam Sinclair (actor), actor
- Adelaide Sinclair, Canadian civil servant
- Aishah Sinclair, Malaysian actress and TV host
- Alex Sinclair, colorist for comics
- Alfred Sinclair, born Alfred Sinclair Wadham, English painter in Australia
- Alfredo Sinclair, Panamanian artist
- Alice Sinclair, British supermodel
- Alison Sinclair (disambiguation)
- Alistair Sinclair, Scottish curler, European champion
- Anders Sinclair, Scottish mercenary in Sweden
- Andrew Sinclair (disambiguation)
- Anne Sinclair, French TV-personality and wife of Dominique Strauss-Kahn
- Archibald Sinclair (journalist) (1866–1922), British sports journalist
- Archibald Sinclair, 1st Viscount Thurso, Scottish politician and leader of the British Liberal Party
- Arthur St. Clair, early American general and President of the Continental Congress
- Arthur Sinclair, early American naval hero
- Ashraf Sinclair, Malaysian actor
- Augustus Sinclair, fictional character from BioShock 2.
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- Dave Sinclair, British musician with the band Caravan
- David Sinclair (disambiguation), multiple people
- Des Sinclair, South Africa international rugby union player
- Donald Sinclair (hotel owner) (1909–1981), owner of the Gleneagles Hotel in Torquay, England; inspiration for the character Basil Fawlty, played by John Cleese, in the British television sitcom Fawlty Towers
- Donald Sinclair (veterinary surgeon) (1911–1995), British veterinary surgeon, inspiration for a character in the All Creatures Great and Small franchise
- Drake Sinclair, fictional character in The Sixth Gun comic series
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The following are people with the surname St. Clair, St Clair or Saint Clair, all of which are traditionally pronounced in the same manner as Sinclair:
- Arthur St. Clair (1737–1818), U.S. revolutionary general
- Blair St. Clair (born 1995), American drag queen
- Bob St. Clair (1931–2015), sportsman
- Earl St. Clair, American musician
- Gairy St. Clair (born 1975), Australian boxer
- Isla St Clair (born 1952), singer
- James D. St. Clair (1920–2001), American lawyer
- James St Clair-Erskine, 2nd Earl of Rosslyn (1762–1837), a Scottish soldier and politician
- Jean Helen St. Clair Campbell, Girl Guide Chief Commissioner for the British Commonwealth
- Jeffrey St. Clair (born 1959), editor
- Lindi St Clair (born 1952), prostitute and political campaigner
- Malcolm St. Clair (filmmaker) (1897–1952), film director, writer, producer, and actor
- Malcolm St Clair (politician) (1927–2004), British Conservative Party politician
- Margaret St. Clair (1911–1995), writer
- Matthew St. Clair, American environmentalist
- Richard St. Clair (born 1946), American composer and poet
- Sally St. Clair (died 1782), a woman soldier in the American Revolution
- Stuart St. Clair (born 1949), Australian lobbyist and politician
- Tavien St. Clair, American football player
- Terry St Clair (born 1951), British singer-songwriter
- Veronica St. Clair (born 1994), American Actress.
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Instances of more than one person with the same name:
- Alison Sinclair (disambiguation)
- Andrew Sinclair (disambiguation)
- Bob Sinclair (disambiguation)
- Charles Sinclair (disambiguation)
- David Sinclair (disambiguation)
- Donald Sinclair (disambiguation)
- Edward Sinclair (disambiguation)
- George Sinclair (disambiguation)
- Ian Sinclair (disambiguation)
- James Sinclair (disambiguation)
- John Sinclair (disambiguation)
- Malcolm Sinclair (disambiguation)
- Michael Sinclair (disambiguation)
- Peter Sinclair (disambiguation)
- William Saint-Clair (disambiguation)
- William Sinclair (disambiguation)
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