Transcription initiation protein SPT3 homolog

Transcription initiation protein SPT3 homolog is a protein that in humans is encoded by the SUPT3H gene.^[5][6][7]

SUPT3H
Identifiers
Aliases	SUPT3H, SPT3, SPT3L, SPT3 homolog, SAGA and STAGA complex component
External IDs	OMIM: 602947; MGI: 1923723; HomoloGene: 121570; GeneCards: SUPT3H; OMA:SUPT3H - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 44,809,317 bp[1] End 45,377,953 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B3 Start 45,088,039 bp[2] End 45,430,177 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad sperm testicle oocyte left testis sural nerve right testis cartilage tissue ventricular zone left ovary Top expressed in hand interventricular septum muscle of thigh primary oocyte zygote seminiferous tubule spermatid otolith organ granulocyte utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity histone acetyltransferase activity transcription coactivator activity DNA binding transcription coregulator activity Cellular component transcription factor TFTC complex nucleus nucleoplasm SAGA complex transcription factor TFIID complex Biological process regulation of transcription by RNA polymerase II positive regulation of transcription, DNA-templated histone deubiquitination regulation of transcription, DNA-templated transcription by RNA polymerase II histone H3 acetylation transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8464 109115 Ensembl ENSG00000196284 ENSMUSG00000038954 UniProt O75486 n/a RefSeq (mRNA) NM_001261823 NM_003599 NM_181356 NM_001350324 NM_001350325 NM_001350326 NM_001350327 NM_001350329 NM_178652 NM_001357320 RefSeq (protein) NP_001248752 NP_003590 NP_852001 NP_001337253 NP_001337254 NP_001337255 NP_001337256 NP_001337258 n/a Location (UCSC) Chr 6: 44.81 – 45.38 Mb Chr 17: 45.09 – 45.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Transcription initiation protein SPT3 homolog has been shown to interact with GCN5L2,^[8][9] TAF6L,^[9] TADA3L,^[9] TAF5L,^[9] SF3B3,^[9] SUPT7L,^[9] Myc,^[10] TAF9,^[9] Transformation/transcription domain-associated protein,^[9] TAF12,^[9] TAF10,^[8][9] TAF4^[8] and DDB1.^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000196284 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038954 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ogryzko VV, Kotani T, Zhang X, Schiltz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (Jul 1998). "Histone-like TAFs within the PCAF histone acetylase complex". Cell. 94 (1): 35–44. doi:10.1016/S0092-8674(00)81219-2. PMID 9674425. S2CID 18942972.
6. Martinez E, Kundu TK, Fu J, Roeder RG (Sep 1998). "A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID". The Journal of Biological Chemistry. 273 (37): 23781–5. doi:10.1074/jbc.273.37.23781. PMID 9726987.
7. "Entrez Gene: SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)".
8. Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (Jun 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595.
9. Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
10. Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.

Further reading

• Yu J, Madison JM, Mundlos S, Winston F, Olsen BR (Oct 1998). "Characterization of a human homologue of the Saccharomyces cerevisiae transcription factor spt3 (SUPT3H)". Genomics. 53 (1): 90–6. doi:10.1006/geno.1998.5500. PMID 9787080.
• Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J, Nakatani Y (Dec 1998). "The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily". Molecular Cell. 2 (6): 869–75. doi:10.1016/S1097-2765(00)80301-9. PMID 9885574.
• Brand M, Yamamoto K, Staub A, Tora L (Jun 1999). "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction". The Journal of Biological Chemistry. 274 (26): 18285–9. doi:10.1074/jbc.274.26.18285. PMID 10373431.
• Speek M (Mar 2001). "Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes". Molecular and Cellular Biology. 21 (6): 1973–85. doi:10.1128/MCB.21.6.1973-1985.2001. PMC 86790. PMID 11238933.
• Brand M, Moggs JG, Oulad-Abdelghani M, Lejeune F, Dilworth FJ, Stevenin J, Almouzni G, Tora L (Jun 2001). "UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation". The EMBO Journal. 20 (12): 3187–96. doi:10.1093/emboj/20.12.3187. PMC 150203. PMID 11406595.
• Martinez E, Palhan VB, Tjernberg A, Lymar ES, Gamper AM, Kundu TK, Chait BT, Roeder RG (Oct 2001). "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo". Molecular and Cellular Biology. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863.
• Cavusoglu N, Brand M, Tora L, Van Dorsselaer A (Feb 2003). "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis". Proteomics. 3 (2): 217–23. doi:10.1002/pmic.200390030. PMID 12601814. S2CID 6035986.
• Liu X, Tesfai J, Evrard YA, Dent SY, Martinez E (May 2003). "c-Myc transformation domain recruits the human STAGA complex and requires TRRAP and GCN5 acetylase activity for transcription activation". The Journal of Biological Chemistry. 278 (22): 20405–12. doi:10.1074/jbc.M211795200. PMC 4031917. PMID 12660246.