Syntaxin binding protein 2

Syntaxin-binding protein 2 is a protein that in humans is encoded by the STXBP2 gene.^[5][6]

STXBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CCA
Identifiers
Aliases	STXBP2, FHL5, Hunc18b, MUNC18-2, UNC18-2, UNC18B, pp10122, Syntaxin binding protein 2
External IDs	OMIM: 601717; MGI: 107370; HomoloGene: 55530; GeneCards: STXBP2; OMA:STXBP2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.2 Start 7,636,881 bp[1] End 7,647,873 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 1.92 cM Start 3,680,955 bp[2] End 3,693,644 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte mucosa of transverse colon body of pancreas upper lobe of left lung right lung right uterine tube left testis right lobe of thyroid gland right testis Top expressed in granulocyte neural layer of retina yolk sac superior frontal gyrus lip right kidney submandibular gland saccule duodenum stomach More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding syntaxin-1 binding syntaxin-3 binding Cellular component cytolytic granule tertiary granule SNARE complex azurophil granule specific granule apical plasma membrane extracellular exosome plasma membrane zymogen granule membrane extracellular region cytosol phagocytic vesicle Biological process protein transport neutrophil degranulation vesicle docking involved in exocytosis regulation of mast cell degranulation leukocyte mediated cytotoxicity vesicle-mediated transport exocytosis platelet degranulation transport cellular response to interferon-gamma Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6813 20911 Ensembl ENSG00000076944 ENSMUSG00000004626 UniProt Q15833 Q64324 RefSeq (mRNA) NM_001127396 NM_001272034 NM_006949 NM_011503 NM_001357168 RefSeq (protein) NP_001120868 NP_001258963 NP_008880 NP_035633 NP_001344097 Location (UCSC) Chr 19: 7.64 – 7.65 Mb Chr 8: 3.68 – 3.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000076944 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004626 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ziegler SF, Mortrud MT, Swartz AR, Baker E, Sutherland GR, Burmeister M, Mulligan JT (Feb 1997). "Molecular characterization of a nonneuronal human UNC18 homolog". Genomics. 37 (1): 19–23. doi:10.1006/geno.1996.0515. PMID 8921365.
6. "Entrez Gene: STXBP2 syntaxin binding protein 2".

Further reading

• Ibaraki K, Horikawa HP, Morita T, et al. (1995). "Identification of four different forms of syntaxin 3". Biochem. Biophys. Res. Commun. 211 (3): 997–1005. doi:10.1006/bbrc.1995.1910. PMID 7598732.
• Hata Y, Südhof TC (1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Tellam JT, Macaulay SL, McIntosh S, et al. (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". J. Biol. Chem. 272 (10): 6179–86. doi:10.1074/jbc.272.10.6179. PMID 9045631.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Riento K, Galli T, Jansson S, et al. (1999). "Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells". J. Cell Sci. 111 (17): 2681–8. doi:10.1242/jcs.111.17.2681. PMID 9701566.
• Riento K, Kauppi M, Keranen S, Olkkonen VM (2000). "Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells". J. Biol. Chem. 275 (18): 13476–83. doi:10.1074/jbc.275.18.13476. PMID 10788461.
• Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
• Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
• Kauppi M, Wohlfahrt G, Olkkonen VM (2003). "Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3". J. Biol. Chem. 277 (46): 43973–9. doi:10.1074/jbc.M208315200. PMID 12198139.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Martin-Verdeaux S, Pombo I, Iannascoli B, et al. (2003). "Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis". J. Cell Sci. 116 (Pt 2): 325–34. doi:10.1242/jcs.00216. PMID 12482918.
• Houng A, Polgar J, Reed GL (2003). "Munc18-syntaxin complexes and exocytosis in human platelets". J. Biol. Chem. 278 (22): 19627–33. doi:10.1074/jbc.M212465200. PMID 12649283.
• Schraw TD, Lemons PP, Dean WL, Whiteheart SW (2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Syntaxin-binding protein 2