SR-144,528

SR144528 is a drug that acts as a potent and highly selective CB₂ receptor inverse agonist, with a K_i of 0.6 nM at CB₂ and 400 nM at the related CB₁ receptor.^[1][2] It is used in scientific research for investigating the function of the CB₂ receptor,^[3][4][5][6] as well as for studying the effects of CB₁ receptors in isolation, as few CB₁ agonists that do not also show significant activity as CB₂ agonists are available.^[7][8][9] It has also been found to be an inhibitor of sterol O-acyltransferase, an effect that appears to be independent from its action on CB₂ receptors.^[10]

SR-144,528

Clinical data
ATC code	none
Identifiers
IUPAC name 5-(4-Chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-yl]-1H-pyrazole-3-carboxamide
CAS Number	192703-06-3 Y
PubChem CID	3081355
IUPHAR/BPS	751
ChemSpider	2338975 N
ChEBI	CHEBI:146245
ChEMBL	ChEMBL381791 N
CompTox Dashboard (EPA)	DTXSID50940947
Chemical and physical data
Formula	C29H34ClN3O
Molar mass	476.06 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC=C(C=C1)CN2C(=CC(=N2)C(=O)N[C@H]3[C@]4(CC[C@H](C4)C3(C)C)C)C5=CC(=C(C=C5)Cl)C
InChI InChI=1S/C29H34ClN3O/c1-18-6-8-20(9-7-18)17-33-25(21-10-11-23(30)19(2)14-21)15-24(32-33)26(34)31-27-28(3,4)22-12-13-29(27,5)16-22/h6-11,14-15,22,27H,12-13,16-17H2,1-5H3,(H,31,34)/t22-,27-,29+/m1/s1 N Key:SUGVYNSRNKFXQM-XRHWURSXSA-N N
NY (what is this?)  (verify)

See also

• NESS-040C5
• Rimonabant
• MN-25