Large neutral amino acids transporter small subunit 2

Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene.^[5][6][7]

SLC7A8
Identifiers
Aliases	SLC7A8, LAT2, LPI-PC1, solute carrier family 7 member 8
External IDs	OMIM: 604235; MGI: 1355323; HomoloGene: 8166; GeneCards: SLC7A8; OMA:SLC7A8 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 23,125,295 bp[1] End 23,183,674 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C2 Start 54,959,666 bp[2] End 55,019,403 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans left uterine tube beta cell gastric mucosa right ovary human kidney left ovary oocyte retinal pigment epithelium decidua Top expressed in yolk sac epithelium of lens right kidney lip islet of Langerhans gastrula decidua superior frontal gyrus muscle of thigh dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptide antigen binding L-amino acid transmembrane transporter activity neutral amino acid transmembrane transporter activity toxin transmembrane transporter activity protein binding antiporter activity organic cation transmembrane transporter activity amino acid transmembrane transporter activity transmembrane transporter activity Cellular component cytoplasm integral component of membrane membrane plasma membrane integral component of plasma membrane basolateral plasma membrane Biological process amino acid transmembrane transport cellular amino acid metabolic process metal ion homeostasis L-amino acid transport L-alpha-amino acid transmembrane transport amino acid transport response to toxic substance neutral amino acid transport leukocyte migration toxin transport organic cation transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23428 50934 Ensembl ENSG00000092068 ENSMUSG00000022180 UniProt Q9UHI5 Q9QXW9 RefSeq (mRNA) NM_001267036 NM_001267037 NM_012244 NM_182728 NM_016972 RefSeq (protein) NP_001253965 NP_001253966 NP_036376 NP_877392 NP_058668 Location (UCSC) Chr 14: 23.13 – 23.18 Mb Chr 14: 54.96 – 55.02 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Heterodimeric amino acid transporter
• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000092068 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022180 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Borsani G, Bassi MT, Sperandeo MP, De Grandi A, Buoninconti A, Riboni M, Manzoni M, Incerti B, Pepe A, Andria G, Ballabio A, Sebastio G (Mar 1999). "SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance". Nat Genet. 21 (3): 297–301. doi:10.1038/6815. PMID 10080183. S2CID 38960307.
6. Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M (Aug 1999). "Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids". J Biol Chem. 274 (28): 19738–44. doi:10.1074/jbc.274.28.19738. hdl:2445/177123. PMID 10391915.
7. "Entrez Gene: SLC7A8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Rossier G, Meier C, Bauch C, et al. (2000). "LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine". J. Biol. Chem. 274 (49): 34948–54. doi:10.1074/jbc.274.49.34948. PMID 10574970.
• Bassi MT, Sperandeo MP, Incerti B, et al. (2000). "SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family". Genomics. 62 (2): 297–303. doi:10.1006/geno.1999.5978. PMID 10610726.
• Bröer A, Friedrich B, Wagner CA, et al. (2001). "Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains". Biochem. J. 355 (Pt 3): 725–31. doi:10.1042/bj3550725. PMC 1221788. PMID 11311135.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Liu X, Charrier L, Gewirtz A, et al. (2003). "CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia". J. Biol. Chem. 278 (26): 23672–7. doi:10.1074/jbc.M302777200. PMID 12716892.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Li S, Whorton AR (2005). "Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols". J. Biol. Chem. 280 (20): 20102–10. doi:10.1074/jbc.M413164200. PMID 15769744.
• Kühne A, Kaiser R, Schirmer M, et al. (2007). "Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan". Pharmacogenet. Genomics. 17 (7): 505–17. doi:10.1097/FPC.0b013e3280ea77cd. PMID 17558306. S2CID 25402443.