Sodium-dependent neutral amino acid transporter B(0)AT2

Sodium-dependent neutral amino acid transporter B(0)AT2 is a protein that in humans is encoded by the SLC6A15 gene.^[5]

SLC6A15
Identifiers
Aliases	SLC6A15, NTT73, SBAT1, V7-3, hv7-3, solute carrier family 6 member 15
External IDs	OMIM: 607971; MGI: 2143484; HomoloGene: 18163; GeneCards: SLC6A15; OMA:SLC6A15 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q21.31 Start 84,859,491 bp[1] End 84,913,629 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D1 Start 103,203,644 bp[2] End 103,255,238 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium prefrontal cortex testicle cerebellar hemisphere Brodmann area 9 right hemisphere of cerebellum middle temporal gyrus Brodmann area 23 ganglionic eminence primary visual cortex Top expressed in saccule barrel cortex ciliary body iris hippocampus proper dentate gyrus cerebellum dentate gyrus of hippocampal formation granule cell secondary oocyte Epithelium of choroid plexus More reference expression data BioGPS n/a
Gene ontology Molecular function neurotransmitter:sodium symporter activity neurotransmitter transmembrane transporter activity symporter activity proline:sodium symporter activity amino acid transmembrane transporter activity Cellular component plasma membrane membrane integral component of plasma membrane integral component of membrane Biological process sodium ion transport proline transport neutral amino acid transport neurotransmitter transport amino acid transport ion transport leucine transport transmembrane transport amino acid transmembrane transport organic acid transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55117 103098 Ensembl ENSG00000072041 ENSMUSG00000019894 UniProt Q9H2J7 Q8BG16 RefSeq (mRNA) NM_001146335 NM_018057 NM_182767 NM_001252330 NM_175328 NM_001358821 RefSeq (protein) NP_001139807 NP_060527 NP_877499 NP_001239259 NP_780537 NP_001345750 Location (UCSC) Chr 12: 84.86 – 84.91 Mb Chr 10: 103.2 – 103.26 Mb PubMed search [3] [4]
Wikidata
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Function

SLC6A15 shows structural characteristics of an Na⁺ and Cl⁻-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.^[6]

Clinical relevance

Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000072041 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019894 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 6 (neutral amino acid transporter)".
6. Farmer MK, Robbins MJ, Medhurst AD, Campbell DA, Ellington K, Duckworth M, Brown AM, Middlemiss DN, Price GW, Pangalos MN (Dec 2000). "Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family". Genomics. 70 (2): 241–52. doi:10.1006/geno.2000.6387. PMID 11112352.
7. Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, Wolf C, Ising M, Schreiber S, Czisch M, Müller MB, Uhr M, Bettecken T, Becker A, Schramm J, Rietschel M, Maier W, Bradley B, Ressler KJ, Nöthen MM, Cichon S, Craig IW, Breen G, Lewis CM, Hofman A, Tiemeier H, van Duijn CM, Holsboer F, Müller-Myhsok B, Binder EB (Apr 2011). "The neuronal transporter gene SLC6A15 confers risk to major depression". Neuron. 70 (2): 252–65. doi:10.1016/j.neuron.2011.04.005. PMC 3112053. PMID 21521612.

Further reading

• Bröer A, Tietze N, Kowalczuk S, Chubb S, Munzinger M, Bak LK, Bröer S (Jan 2006). "The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2)". The Biochemical Journal. 393 (Pt 1): 421–30. doi:10.1042/BJ20051273. PMC 1383701. PMID 16185194.
• Zaia KA, Reimer RJ (Mar 2009). "Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport". The Journal of Biological Chemistry. 284 (13): 8439–48. doi:10.1074/jbc.M806407200. PMC 2659202. PMID 19147495.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Bröer S (Jan 2008). "Amino acid transport across mammalian intestinal and renal epithelia". Physiological Reviews. 88 (1): 249–86. doi:10.1152/physrev.00018.2006. PMID 18195088.
• Takanaga H, Mackenzie B, Peng JB, Hediger MA (Nov 2005). "Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain". Biochemical and Biophysical Research Communications. 337 (3): 892–900. doi:10.1016/j.bbrc.2005.09.128. PMID 16226721.
• Masson J, Sagné C, Hamon M, El Mestikawy S (Sep 1999). "Neurotransmitter transporters in the central nervous system". Pharmacological Reviews. 51 (3): 439–64. PMID 10471414.