Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.[5][6][7]
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The SMVT is a transporter for pantothenic acid (vitamin B5) and biotin (vitamin B7) at the blood–brain barrier.[8] It is also a transporter for alpha lipoic acid[9] and iodide. Transport of these nutrients is competitive[10] and a surplus of a given nutrient may saturate the transporter and prevent the uptake of other nutrients.
Chirapu SR, Rotter CJ, Miller EL, Varma MV, Dow RL, Finn MG (31 March 2013). "High specificity in response of the sodium-dependent multivitamin transporter to derivatives of pantothenic acid". Current Topics in Medicinal Chemistry. 13 (7): 837–42. doi:10.2174/1568026611313070006. PMID 23578027.
- Prasad PD, Wang H, Huang W, Fei YJ, Leibach FH, Devoe LD, Ganapathy V (June 1999). "Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter". Archives of Biochemistry and Biophysics. 366 (1): 95–106. doi:10.1006/abbi.1999.1213. PMID 10334869.
- Zempleni J, Steven Stanley J, Mock DM (August 2001). "Proliferation of peripheral blood mononuclear cells causes increased expression of the sodium-dependent multivitamin transporter gene and increased uptake of pantothenic acidopen star". The Journal of Nutritional Biochemistry. 12 (8): 465–473. doi:10.1016/S0955-2863(01)00162-0. PMID 11834205.
- Dey S, Subramanian VS, Chatterjee NS, Rubin SA, Said HM (March 2002). "Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT". Biochimica et Biophysica Acta. 1574 (2): 187–92. doi:10.1016/s0167-4781(02)00226-9. PMID 11955628.
- Balamurugan K, Ortiz A, Said HM (July 2003). "Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system". American Journal of Physiology. Gastrointestinal and Liver Physiology. 285 (1): G73-7. doi:10.1152/ajpgi.00059.2003. PMID 12646417.
- Balamurugan K, Vaziri ND, Said HM (April 2005). "Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects". American Journal of Physiology. Renal Physiology. 288 (4): F823-31. doi:10.1152/ajprenal.00375.2004. PMID 15561972.
- Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Luo S, Kansara VS, Zhu X, Mandava NK, Pal D, Mitra AK (2006). "Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery". Molecular Pharmaceutics. 3 (3): 329–39. doi:10.1021/mp0500768. PMC 2553563. PMID 16749865.
- Reidling JC, Nabokina SM, Said HM (January 2007). "Molecular mechanisms involved in the adaptive regulation of human intestinal biotin uptake: A study of the hSMVT system". American Journal of Physiology. Gastrointestinal and Liver Physiology. 292 (1): G275-81. doi:10.1152/ajpgi.00327.2006. PMID 16959947. S2CID 575953.
- Reidling JC, Said HM (April 2007). "Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo". American Journal of Physiology. Cell Physiology. 292 (4): C1305-12. doi:10.1152/ajpcell.00360.2006. PMID 17135299.