Sodium/myo-inositol cotransporter

Sodium/myo-inositol cotransporter is a protein that in humans is encoded by the SLC5A3 gene.^[5][6]

SLC5A3
Identifiers
Aliases	SLC5A3, BCW2, SMIT, SMIT1, SMIT2, solute carrier family 5 member 3
External IDs	OMIM: 600444; MGI: 1858226; HomoloGene: 31412; GeneCards: SLC5A3; OMA:SLC5A3 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.11 Start 34,073,578 bp[1] End 34,106,260 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C4 Start 91,855,210 bp[2] End 91,884,361 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla Epithelium of choroid plexus tibia cartilage tissue retinal pigment epithelium trabecular bone trigeminal ganglion spinal ganglia visceral pleura mucosa of paranasal sinus Top expressed in vestibular membrane of cochlear duct ciliary body iris Epithelium of choroid plexus vestibular sensory epithelium calvaria sciatic nerve pineal gland endothelial cell of lymphatic vessel retinal pigment epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function myo-inositol:sodium symporter activity symporter activity transmembrane transporter activity glucose:sodium symporter activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process regulation of respiratory gaseous exchange peripheral nervous system development ion transport sodium ion transport inositol metabolic process transmembrane transport myo-inositol transport glucose transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6526 53881 Ensembl ENSG00000198743 ENSMUSG00000089774 UniProt P53794 Q9JKZ2 RefSeq (mRNA) NM_006933 NM_017391 RefSeq (protein) n/a NP_059087 Location (UCSC) Chr 21: 34.07 – 34.11 Mb Chr 16: 91.86 – 91.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Expression of the myo-inositol transport protein is regulated by osmotic stress.^[7]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000198743 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000089774 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Berry GT, Mallee JJ, Kwon HM, Rim JS, Mulla WR, Muenke M, Spinner NB (Jul 1995). "The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21". Genomics. 25 (2): 507–13. doi:10.1016/0888-7543(95)80052-N. PMID 7789985.
6. "Entrez Gene: SLC5A3 solute carrier family 5 (inositol transporters), member 3".
7. Lee SD, Choi SY, Lim SW, Lamitina ST, Ho SN, Go WY, Kwon HM (2011). "TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: Organic osmolyte-dependent and -independent pathways". AJP: Renal Physiology. 300 (3): F707–F715. doi:10.1152/ajprenal.00227.2010. PMC 3064130. PMID 21209002.

Further reading

• Kwon HM, Yamauchi A, Uchida S, et al. (1992). "Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein". J. Biol. Chem. 267 (9): 6297–301. doi:10.1016/S0021-9258(18)42695-6. PMID 1372904.
• Berry GT, Mallee JJ, Blouin JL, Antonarakis SE (1996). "The 21q22.1 STS marker, VN02 (EST00541 cDNA), is part of the 3' sequence of the human Na+/myo-inositol cotransporter (SLC5A3) gene". Cytogenet. Cell Genet. 73 (1–2): 77–8. doi:10.1159/000134311. PMID 8646889.
• Mallee JJ, Atta MG, Lorica V, et al. (1998). "The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter". Genomics. 46 (3): 459–65. doi:10.1006/geno.1997.5055. PMID 9441750.
• Porcellati F, Hlaing T, Togawa M, et al. (1998). "Human Na(+)-myo-inositol cotransporter gene: alternate splicing generates diverse transcripts". Am. J. Physiol. 274 (5 Pt 1): C1215–25. doi:10.1152/ajpcell.1998.274.5.C1215. PMID 9612208. S2CID 22626824.
• Rim JS, Atta MG, Dahl SC, et al. (1998). "Transcription of the Sodium/myo-Inositol Cotransporter Gene Is Regulated by Multiple Tonicity-responsive Enhancers Spread over 50 Kilobase Pairs in the 5′-Flanking Region". J. Biol. Chem. 273 (32): 20615–21. doi:10.1074/jbc.273.32.20615. PMC 2365891. PMID 9685419.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Thangaraju M, Gopal E, Martin PM, et al. (2007). "SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases". Cancer Res. 66 (24): 11560–4. doi:10.1158/0008-5472.CAN-06-1950. PMID 17178845.