Choline transporter-like protein 4

Choline transporter-like protein 4 is a protein that in humans is encoded by the SLC44A4 gene.^[5][6][7]

SLC44A4
Identifiers
Aliases	SLC44A4, C6orf29, CTL4, NG22, TPPT, solute carrier family 44 member 4, DFNA72, hTPPT1
External IDs	OMIM: 606107; MGI: 1917379; HomoloGene: 11359; GeneCards: SLC44A4; OMA:SLC44A4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,863,192 bp[1] End 31,879,046 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 35,133,442 bp[2] End 35,149,412 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right uterine tube rectum duodenum olfactory zone of nasal mucosa gallbladder prostate islet of Langerhans human kidney appendix Top expressed in left colon epithelium of stomach ileum intestinal villus Ileal epithelium mucous cell of stomach right kidney pyloric antrum jejunum proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function choline transmembrane transporter activity thiamine pyrophosphate transmembrane transporter activity Cellular component extracellular exosome membrane integral component of membrane plasma membrane apical plasma membrane Biological process acetylcholine secretion phosphatidylcholine biosynthetic process transmembrane transport acetylcholine biosynthetic process positive regulation of cell growth choline transport thiamine pyrophosphate transmembrane transport otolith formation neuromast hair cell development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80736 70129 Ensembl ENSG00000232180 ENSG00000204385 ENSG00000231479 ENSG00000228263 ENSG00000206378 ENSG00000235336 ENSG00000229077 ENSG00000203463 ENSMUSG00000007034 UniProt Q53GD3 Q91VA1 RefSeq (mRNA) NM_025257 NM_001178044 NM_001178045 NM_023557 RefSeq (protein) NP_001171515 NP_001171516 NP_079533 NP_076046 Location (UCSC) Chr 6: 31.86 – 31.88 Mb Chr 17: 35.13 – 35.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

References

1. ENSG00000204385, ENSG00000231479, ENSG00000228263, ENSG00000206378, ENSG00000235336, ENSG00000229077, ENSG00000203463 GRCh38: Ensembl release 89: ENSG00000232180, ENSG00000204385, ENSG00000231479, ENSG00000228263, ENSG00000206378, ENSG00000235336, ENSG00000229077, ENSG00000203463 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000007034 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. O'Regan S, Traiffort E, Ruat M, Cha N, Compaore D, Meunier FM (Mar 2000). "An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins". Proc Natl Acad Sci U S A. 97 (4): 1835–40. Bibcode:2000PNAS...97.1835O. doi:10.1073/pnas.030339697. PMC 26522. PMID 10677542.
6. Traiffort E, Ruat M, O'Regan S, Meunier FM (Feb 2005). "Molecular characterization of the family of choline transporter-like proteins and their splice variants". J Neurochem. 92 (5): 1116–25. doi:10.1111/j.1471-4159.2004.02962.x. PMID 15715662. S2CID 30921826.
7. "Entrez Gene: SLC44A4 solute carrier family 44, member 4".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Uhl J, Penzel R, Sergi C, et al. (2002). "Identification of a CTL4/Neu1 fusion transcript in a sialidosis patient". FEBS Lett. 521 (1–3): 19–23. doi:10.1016/S0014-5793(02)02748-5. PMID 12067718. S2CID 23180217.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.