Glucose-6-phosphate exchanger SLC37A1

Glucose-6-phosphate exchanger SLC37A1 is a protein that in humans is encoded by the SLC37A1 gene.^[5] SLC37A1 locates to the membrane of the endoplasmic reticulum (ER), and is a glucose 6-phosphate:inorganic phosphate antiporter, transporting glucose 6-phosphate from the cytoplasm into the lumen of the ER, while transporting phosphate in the opposite direction.^[6]

SLC37A1
Identifiers
Aliases	SLC37A1, G3PP, solute carrier family 37 member 1
External IDs	OMIM: 608094; MGI: 2446181; HomoloGene: 70486; GeneCards: SLC37A1; OMA:SLC37A1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 42,496,008 bp[1] End 42,581,440 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 31,505,766 bp[2] End 31,569,713 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa left testis right uterine tube rectum anterior pituitary right testis gallbladder transverse colon minor salivary glands duodenum Top expressed in colon intestinal villus crypt of lieberkuhn of small intestine duodenum left colon jejunum embryo pyloric antrum granulocyte gastric mucosa More reference expression data BioGPS n/a
Gene ontology Molecular function transporter activity antiporter activity glucose 6-phosphate:inorganic phosphate antiporter activity transmembrane transporter activity Cellular component integral component of endoplasmic reticulum membrane membrane endoplasmic reticulum integral component of membrane endoplasmic reticulum membrane Biological process phosphate ion transmembrane transport carbohydrate transport transmembrane transport glucose-6-phosphate transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54020 224674 Ensembl ENSG00000160190 ENSMUSG00000024036 UniProt P57057 Q8R070 RefSeq (mRNA) NM_018964 NM_001320537 NM_001242427 NM_153062 RefSeq (protein) NP_001307466 NP_061837 NP_001229356 NP_694702 Location (UCSC) Chr 21: 42.5 – 42.58 Mb Chr 17: 31.51 – 31.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Unlike the related SLC37A4 protein, SLC37A1 does not appear to be involved in blood glucose homeostasis,^[7] but does appear to regulate phosphate levels in the milk of cows, with flow-on effects on the volume of milk produced.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000160190 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024036 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 37 (glucose-6-phosphate transporter), member 1".
6. "SLC37A1 - Glucose-6-phosphate exchanger SLC37A1 - Homo sapiens (Human) - SLC37A1 gene & protein".
7. Pan CJ, Chen SY, Jun HS, Lin SR, Mansfield BC, Chou JY (2011). "SLC37A1 and SLC37A2 are phosphate-linked, glucose-6-phosphate antiporters". PLOS ONE. 6 (9): e23157. Bibcode:2011PLoSO...623157P. doi:10.1371/journal.pone.0023157. PMC 3176764. PMID 21949678.
8. Kemper KE, Littlejohn MD, Lopdell T, Hayes BJ, Bennett LE, Williams RP, Xu XQ, Visscher PM, Carrick MJ, Goddard ME (2016). "Leveraging genetically simple traits to identify small-effect variants for complex phenotypes". BMC Genomics. 17 (1): 858. doi:10.1186/s12864-016-3175-3. PMC 5094043. PMID 27809761.

Further reading

• Bartoloni L, Antonarakis SE (February 2004). "The human sugar-phosphate/phosphate exchanger family SLC37". Pflügers Archiv. 447 (5): 780–3. doi:10.1007/s00424-003-1105-0. PMID 12811562. S2CID 24776306.