Sodium-dependent phosphate transport protein 2B

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.^[5][6][7]

SLC34A2
Identifiers
Aliases	SLC34A2, NAPI-3B, NAPI-IIb, NPTIIb, solute carrier family 34 member 2, PULAM
External IDs	OMIM: 604217; MGI: 1342284; HomoloGene: 2297; GeneCards: SLC34A2; OMA:SLC34A2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.2 Start 25,648,011 bp[1] End 25,678,748 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C1|5 28.92 cM Start 53,195,423 bp[2] End 53,229,006 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung palpebral conjunctiva upper lobe of lung upper lobe of left lung bronchial epithelial cell right lung right uterine tube endometrium minor salivary glands right lobe of thyroid gland Top expressed in left lung left lung lobe right lung right lung lobe ileum jejunum spermatocyte spermatid corneal stroma morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphate ion binding sodium ion binding sodium:phosphate symporter activity symporter activity Cellular component integral component of membrane vesicle membrane plasma membrane integral component of plasma membrane brush border membrane apical plasma membrane brush border cytoplasm Biological process phosphate ion transport sodium-dependent phosphate transport sodium ion transport cellular phosphate ion homeostasis in utero embryonic development response to estrogen phosphate ion transmembrane transport sodium ion transmembrane transport ion transport transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10568 20531 Ensembl ENSG00000157765 ENSMUSG00000029188 UniProt O95436 Q9DBP0 RefSeq (mRNA) NM_006424 NM_001177998 NM_001177999 NM_011402 RefSeq (protein) NP_001171469 NP_001171470 NP_006415 NP_035532 Location (UCSC) Chr 4: 25.65 – 25.68 Mb Chr 5: 53.2 – 53.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Clinical significance

Sodium-dependent phosphate transport protein 2b (NaPi2b) is a tumor-associated antigen.^[8]

As of April 2023, upifitamab rilsodotin, an antibody-drug conjugate (ADC) targeting NaPi2b, is in Phase 3 clinical trials for recurrent platinum-sensitive ovarian cancer.^[9]

See also

• Solute carrier family
• Pulmonary alveolar microlithiasis

References

1. GRCh38: Ensembl release 89: ENSG00000157765 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029188 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Feild JA, Zhang L, Brun KA, Brooks DP, Edwards RM (May 1999). "Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine". Biochemical and Biophysical Research Communications. 258 (3): 578–582. doi:10.1006/bbrc.1999.0666. PMID 10329428.
6. Xu H, Bai L, Collins JF, Ghishan FK (December 1999). "Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)". Genomics. 62 (2): 281–284. doi:10.1006/geno.1999.6009. PMID 10610722.
7. "Entrez Gene: SLC34A2 solute carrier family 34 (sodium phosphate), member 2".
8. Yin BW, Kiyamova R, Chua R, Caballero OL, Gout I, Gryshkova V, et al. (February 2008). "Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas". Cancer Immunity. 8: 3. PMC 2935786. PMID 18251464.
9. Clinical trial number NCT05329545 for "Upifitamab Rilsodotin Maintenance in Platinum-Sensitive Recurrent Ovarian Cancer (UP-NEXT)." at ClinicalTrials.gov

Further reading

• Xu H, Collins JF, Bai L, Kiela PR, Ghishan FK (March 2001). "Regulation of the human sodium-phosphate cotransporter NaP(i)-IIb gene promoter by epidermal growth factor". American Journal of Physiology. Cell Physiology. 280 (3): C628–C636. doi:10.1152/ajpcell.2001.280.3.C628. PMID 11171583. S2CID 7439508.
• Segawa H, Kaneko I, Takahashi A, Kuwahata M, Ito M, Ohkido I, et al. (May 2002). "Growth-related renal type II Na/Pi cotransporter". The Journal of Biological Chemistry. 277 (22): 19665–19672. doi:10.1074/jbc.M200943200. PMID 11880379.
• Xu H, Uno JK, Inouye M, Collins JF, Ghishan FK (February 2005). "NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene". American Journal of Physiology. Gastrointestinal and Liver Physiology. 288 (2): G175–G181. doi:10.1152/ajpgi.00396.2004. PMID 15458926. S2CID 14194207.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Corut A, Senyigit A, Ugur SA, Altin S, Ozcelik U, Calisir H, et al. (October 2006). "Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis". American Journal of Human Genetics. 79 (4): 650–656. doi:10.1086/508263. PMC 1592565. PMID 16960801.
• Izumi S, Miyazawa H, Ishii K, Uchiyama B, Ishida T, Tanaka S, et al. (February 2007). "Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis". American Journal of Respiratory and Critical Care Medicine. 175 (3): 263–268. doi:10.1164/rccm.200609-1274OC. PMID 17095743.