Zinc transporter 3

Zinc transporter 3 also known as solute carrier family 30 member 3 is a protein in humans that is encoded by the SLC30A3 gene.^[5]

SLC30A3
Identifiers
Aliases	SLC30A3, ZNT3, solute carrier family 30 member 3
External IDs	OMIM: 602878; MGI: 1345280; HomoloGene: 74470; GeneCards: SLC30A3; OMA:SLC30A3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 27,253,684 bp[1] End 27,275,817 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B1|5 16.97 cM Start 31,243,450 bp[2] End 31,265,581 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis Brodmann area 10 left testis right testis endothelial cell right frontal lobe dorsolateral prefrontal cortex Brodmann area 9 Brodmann area 46 middle temporal gyrus Top expressed in entorhinal cortex perirhinal cortex zygote CA3 field visual cortex primary visual cortex secondary oocyte superior frontal gyrus dentate gyrus of hippocampal formation granule cell Ileal epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function ABC-type zinc transporter activity protein binding cation transmembrane transporter activity zinc ion transmembrane transporter activity Cellular component synapse integral component of plasma membrane late endosome membrane lysosomal membrane synaptic vesicle membrane cytoplasm endosome cell junction lysosome integral component of membrane late endosome membrane cytoplasmic vesicle neuron projection synaptic vesicle integral component of synaptic vesicle membrane hippocampal mossy fiber to CA3 synapse glutamatergic synapse plasma membrane Biological process response to zinc ion ion transport positive regulation of transport cation transport regulation of sequestering of zinc ion cation transmembrane transport zinc ion transport zinc ion transmembrane transport transmembrane transport zinc ion import into synaptic vesicle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7781 22784 Ensembl ENSG00000115194 ENSMUSG00000029151 UniProt Q99726 P97441 RefSeq (mRNA) NM_003459 NM_001318949 NM_001318950 NM_001318951 NM_011773 NM_001347323 RefSeq (protein) NP_001305878 NP_001305879 NP_001305880 NP_003450 NP_001334252 NP_035903 Location (UCSC) Chr 2: 27.25 – 27.28 Mb Chr 5: 31.24 – 31.27 Mb PubMed search [3] [4]
Wikidata
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The SLC30A3 gene codes for the ZnT-3 SLC30A family membrane transport protein. ZnT-3 is required for the accumulation of zinc ions inside synaptic vesicles.^[6] In mice, ZnT-3 is required for some forms of memory that depend on the hippocampus and the amygdala.^[7] Zinc transport by ZnT-3 modulates memory formation by acting through the extracellular signal-regulated kinases signaling pathway.^[8] Angiotensin II-induced senescence of vascular smooth muscle cells requires down-regulation of ZnT-3 and ZnT-10.^[9]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000115194 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029151 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Solute carrier family 30 (zinc transporter), member 3".
6. Cole TB, Wenzel HJ, Kafer KE, Schwartzkroin PA, Palmiter RD (February 1999). "Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (4): 1716–21. Bibcode:1999PNAS...96.1716C. doi:10.1073/pnas.96.4.1716. PMC 15571. PMID 9990090.
7. Sindreu C, Storm DR (2011). "Modulation of neuronal signal transduction and memory formation by synaptic zinc". Frontiers in Behavioral Neuroscience. 5: 68. doi:10.3389/fnbeh.2011.00068. PMC 3211062. PMID 22084630.
8. Mott DD, Dingledine R (February 2011). "Unraveling the role of zinc in memory". Proceedings of the National Academy of Sciences of the United States of America. 108 (8): 3103–4. Bibcode:2011PNAS..108.3103M. doi:10.1073/pnas.1100323108. PMC 3044369. PMID 21321213.
9. Patrushev N, Seidel-Rogol B, Salazar G (2012). "Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells". PLOS ONE. 7 (3): e33211. Bibcode:2012PLoSO...733211P. doi:10.1371/journal.pone.0033211. PMC 3299759. PMID 22427991.