Folate transporter 1

Folate transporter 1 is a protein which in humans is encoded by the SLC19A1 gene.^[5]

SLC19A1
Identifiers
Aliases	SLC19A1, CHMD, FOLT, IFC1, REFC, RFC1, solute carrier family 19 member 1, IFC-1, RFC, hRFC, RFT-1, hMEGAF
External IDs	OMIM: 600424; MGI: 103182; HomoloGene: 57139; GeneCards: SLC19A1; OMA:SLC19A1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 45,493,572 bp[1] End 45,573,365 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 77,032,241 bp[2] End 77,061,002 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa blood endothelial cell Epithelium of choroid plexus retinal pigment epithelium duodenum gallbladder stromal cell of endometrium right lung putamen Top expressed in Paneth cell right kidney retinal pigment epithelium vestibular membrane of cochlear duct choroid plexus of fourth ventricle ciliary body Epithelium of choroid plexus human kidney crypt of lieberkuhn of small intestine endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function folic acid binding methotrexate transmembrane transporter activity vitamin transmembrane transporter activity folic acid transmembrane transporter activity folate:anion antiporter activity Cellular component integral component of membrane integral component of plasma membrane apical plasma membrane membrane basolateral plasma membrane plasma membrane Biological process folic acid metabolic process folate transmembrane transport folic acid transport methotrexate transport vitamin transport folate import across plasma membrane transmembrane transport vitamin transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6573 20509 Ensembl ENSG00000173638 ENSMUSG00000001436 UniProt P41440 P41438 RefSeq (mRNA) NM_001205206 NM_001205207 NM_003056 NM_194255 NM_001352510 NM_001352511 NM_001352512 NM_001199271 NM_031196 RefSeq (protein) NP_001192135 NP_001192136 NP_919231 NP_001339439 NP_001339440 NP_001339441 NP_001186200 NP_112473 Location (UCSC) Chr 21: 45.49 – 45.57 Mb Chr 10: 77.03 – 77.06 Mb PubMed search [3] [4]
Wikidata
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Function

Transport of folate compounds into mammalian cells can occur via receptor-mediated (see folate receptor 1) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.^[6] SLC19A1 has also been shown to transport the immune second messenger 2'3'-cGAMP.^[7]

Clinical significance

Individuals carrying a specific polymorphism of SLC19A1 (c.80GG) have lower levels of folate.^[8] Other studies have also shown that individuals carrying the c.80AA polymorphism who are treated with methotrexate have higher levels of this anti-folate chemotherapeutic agent. Personalized dosing of the drug depending on the patient's genotype may therefore be required.

Alternative names

• Reduced folate carrier 1
• Intestinal folate carrier 1

See also

• Solute carrier family
• Folate-binding protein
• Reduced folate carrier family