Vesicular glutamate transporter 1

Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.^[5][6][7]

SLC17A7
Identifiers
Aliases	SLC17A7, BNPI, VGLUT1, solute carrier family 17 member 7
External IDs	OMIM: 605208; MGI: 1920211; HomoloGene: 113454; GeneCards: SLC17A7; OMA:SLC17A7 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,429,401 bp[1] End 49,442,360 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B3 Start 44,813,373 bp[2] End 44,825,566 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe superior frontal gyrus Brodmann area 10 frontal pole Region I of hippocampus proper middle temporal gyrus Brodmann area 46 dorsolateral prefrontal cortex orbitofrontal cortex Top expressed in neural layer of retina dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus prefrontal cortex piriform cortex cerebellar cortex hippocampus proper primary motor cortex subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function inorganic phosphate transmembrane transporter activity sodium:inorganic phosphate symporter activity extracellularly glutamate-gated chloride channel activity symporter activity L-glutamate transmembrane transporter activity neurotransmitter transmembrane transporter activity Cellular component postsynapse integral component of membrane membrane synaptic vesicle plasma membrane synapse excitatory synapse synaptic vesicle membrane cerebellar mossy fiber presynaptic active zone cell junction intracellular organelle neuron projection clathrin-sculpted glutamate transport vesicle membrane cytoplasmic vesicle integral component of synaptic vesicle membrane Biological process phosphate ion transport synaptic transmission, glutamatergic sodium-dependent phosphate transport sodium ion transport chloride transmembrane transport ion transport glutamate secretion synaptic vesicle lumen acidification brain development long-term memory excitatory postsynaptic potential neurotransmitter transport neural retina development L-glutamate import sequestering of neurotransmitter sodium ion transmembrane transport transmembrane transport chemical synaptic transmission neurotransmitter loading into synaptic vesicle L-glutamate transmembrane transport regulation of synaptic vesicle endocytosis regulation of synapse structure or activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57030 72961 Ensembl ENSG00000104888 ENSMUSG00000070570 UniProt Q9P2U7 Q3TXX4 RefSeq (mRNA) NM_020309 NM_182993 RefSeq (protein) NP_064705 NP_892038 Location (UCSC) Chr 19: 49.43 – 49.44 Mb Chr 7: 44.81 – 44.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family.^[7]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000104888 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070570 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ni B, Du Y, Wu X, DeHoff BS, Rosteck PR Jr, Paul SM (Jul 1996). "Molecular cloning, expression, and chromosomal localization of a human brain-specific Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 66 (6): 2227–38. doi:10.1046/j.1471-4159.1996.66062227.x. PMID 8632143. S2CID 23177236.
6. Aihara Y, Mashima H, Onda H, Hisano S, Kasuya H, Hori T, Yamada S, Tomura H, Yamada Y, Inoue I, Kojima I, Takeda J (Jun 2000). "Molecular cloning of a novel brain-type Na(+)-dependent inorganic phosphate cotransporter". J Neurochem. 74 (6): 2622–5. doi:10.1046/j.1471-4159.2000.0742622.x. PMID 10820226. S2CID 37857748.
7. "Entrez Gene: SLC17A7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7".

Further reading

• Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH (2000). "Uptake of glutamate into synaptic vesicles by an inorganic phosphate transporter". Science. 289 (5481): 957–60. Bibcode:2000Sci...289..957B. doi:10.1126/science.289.5481.957. PMID 10938000.
• Takamori S, Rhee JS, Rosenmund C, Jahn R (2000). "Identification of a vesicular glutamate transporter that defines a glutamatergic phenotype in neurons". Nature. 407 (6801): 189–94. Bibcode:2000Natur.407..189T. doi:10.1038/35025070. hdl:11858/00-001M-0000-0012-F987-C. PMID 11001057. S2CID 4412622.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Eastwood SL, Harrison PJ (2005). "Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons". Schizophrenia Research. 73 (2–3): 159–72. doi:10.1016/j.schres.2004.05.010. PMID 15653259. S2CID 2335413.
• Alonso-Nanclares L, De Felipe J (2005). "Vesicular glutamate transporter 1 immunostaining in the normal and epileptic human cerebral cortex". Neuroscience. 134 (1): 59–68. doi:10.1016/j.neuroscience.2005.03.038. PMID 15961236. S2CID 25943855.
• Vinatier J, Herzog E, Plamont MA, et al. (2006). "Interaction between the vesicular glutamate transporter type 1 and endophilin A1, a protein essential for endocytosis". J. Neurochem. 97 (4): 1111–25. doi:10.1111/j.1471-4159.2006.03821.x. PMID 16606361. S2CID 3133505.
• Almqvist J, Huang Y, Laaksonen A, et al. (2007). "Docking and homology modeling explain inhibition of the human vesicular glutamate transporters". Protein Sci. 16 (9): 1819–29. doi:10.1110/ps.072944707. PMC 2206968. PMID 17660252.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.