Monocarboxylate transporter 5

Monocarboxylate transporter 5 is a protein that in humans is encoded by the SLC16A4 gene.^[5][6]

SLC16A4
Identifiers
Aliases	SLC16A4, MCT4, MCT5, solute carrier family 16 member 4
External IDs	OMIM: 603878; MGI: 2385183; HomoloGene: 74529; GeneCards: SLC16A4; OMA:SLC16A4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 110,362,851 bp[1] End 110,391,082 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.3 Start 107,198,546 bp[2] End 107,219,431 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva kidney tubule glomerulus metanephric glomerulus retinal pigment epithelium corpus epididymis placenta caput epididymis jejunal mucosa human kidney Top expressed in right kidney human kidney proximal tubule calvaria Epithelium of choroid plexus spermatocyte tail of embryo ventricular zone neural layer of retina embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function symporter activity monocarboxylic acid transmembrane transporter activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process monocarboxylic acid transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9122 229699 Ensembl ENSG00000168679 ENSMUSG00000027896 UniProt O15374 Q8R0M8 RefSeq (mRNA) NM_001201546 NM_001201547 NM_001201548 NM_001201549 NM_004696 NM_001319220 NM_146136 NM_001310705 RefSeq (protein) NP_001188475 NP_001188476 NP_001188477 NP_001188478 NP_001306149 NP_004687 NP_001297634 NP_666248 Location (UCSC) Chr 1: 110.36 – 110.39 Mb Chr 3: 107.2 – 107.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000168679 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027896 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Price NT, Jackson VN, Halestrap AP (January 1998). "Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past". The Biochemical Journal. 329 (2): 321–8. doi:10.1042/bj3290321. PMC 1219047. PMID 9425115.
6. "Entrez Gene: SLC16A4 solute carrier family 16, member 4 (monocarboxylic acid transporter 5)".

Further reading

• Halestrap AP, Price NT (October 1999). "The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation". The Biochemical Journal. 343 (2): 281–99. doi:10.1042/bj3430281. PMC 1220552. PMID 10510291.
• Halestrap AP, Meredith D (February 2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Archiv. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169. S2CID 15498611.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Pilegaard H, Terzis G, Halestrap A, Juel C (May 1999). "Distribution of the lactate/H+ transporter isoforms MCT1 and MCT4 in human skeletal muscle". The American Journal of Physiology. 276 (5 Pt 1): E843-8. doi:10.1152/ajpendo.1999.276.5.E843. PMID 10329977.
• Manning Fox JE, Meredith D, Halestrap AP (December 2000). "Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle". The Journal of Physiology. 529 (2): 285–93. doi:10.1111/j.1469-7793.2000.00285.x. PMC 2270204. PMID 11101640.
• Philp NJ, Wang D, Yoon H, Hjelmeland LM (April 2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells". Investigative Ophthalmology & Visual Science. 44 (4): 1716–21. doi:10.1167/iovs.02-0287. PMID 12657613.
• Juel C, Holten MK, Dela F (April 2004). "Effects of strength training on muscle lactate release and MCT1 and MCT4 content in healthy and type 2 diabetic humans". The Journal of Physiology. 556 (Pt 1): 297–304. doi:10.1113/jphysiol.2003.058222. PMC 1664883. PMID 14724187.
• Settle P, Mynett K, Speake P, Champion E, Doughty IM, Sibley CP, D'Souza SW, Glazier J (July 2004). "Polarized lactate transporter activity and expression in the syncytiotrophoblast of the term human placenta". Placenta. 25 (6): 496–504. doi:10.1016/j.placenta.2003.11.009. PMID 15135232.
• Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP (July 2005). "Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)". The Journal of Biological Chemistry. 280 (29): 27213–21. doi:10.1074/jbc.M411950200. PMID 15917240.
• Merezhinskaya N, Ogunwuyi SA, Fishbein WN (February 2006). "Expression of monocarboxylate transporter 4 in human platelets, leukocytes, and tissues assessed by antibodies raised against terminal versus pre-terminal peptides". Molecular Genetics and Metabolism. 87 (2): 152–61. doi:10.1016/j.ymgme.2005.09.029. PMID 16403666.
• Bickham DC, Bentley DJ, Le Rossignol PF, Cameron-Smith D (April 2006). "The effects of short-term sprint training on MCT expression in moderately endurance-trained runners". European Journal of Applied Physiology. 96 (6): 636–43. doi:10.1007/s00421-005-0100-x. PMID 16408234. S2CID 10354316.
• Ullah MS, Davies AJ, Halestrap AP (April 2006). "The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism". The Journal of Biological Chemistry. 281 (14): 9030–7. doi:10.1074/jbc.M511397200. PMID 16452478.
• Bishop D, Edge J, Thomas C, Mercier J (February 2007). "High-intensity exercise acutely decreases the membrane content of MCT1 and MCT4 and buffer capacity in human skeletal muscle". Journal of Applied Physiology. 102 (2): 616–21. doi:10.1152/japplphysiol.00590.2006. PMID 17082373. S2CID 336956.