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SB-228357 is a drug which acts as a selective antagonist of the serotonin 5-HT2B and 5-HT2C receptors.[1][2]

Quick Facts Identifiers, CAS Number ...
SB-228357
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Identifiers
  • N-(3-fluoro-5-pyridin-3-ylphenyl)-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide
CAS Number
PubChem CID
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KEGG
ChEBI
ChEMBL
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Chemical and physical data
FormulaC22H17F4N3O2
Molar mass431.391 g·mol−1
3D model (JSmol)
  • COC1=C(C=C2C(=C1)CCN2C(=O)NC3=CC(=CC(=C3)C4=CN=CC=C4)F)C(F)(F)F
  • InChI=1S/C22H17F4N3O2/c1-31-20-9-13-4-6-29(19(13)11-18(20)22(24,25)26)21(30)28-17-8-15(7-16(23)10-17)14-3-2-5-27-12-14/h2-3,5,7-12H,4,6H2,1H3,(H,28,30)
  • Key:RRJLJKRFFRZRAF-UHFFFAOYSA-N
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It has antidepressant and anxiolytic effects in animal models[1][2] and inhibits 5-HT2B mediated proliferation of cardiac fibroblasts.[3] It has also been found to reverse meta-chlorophenylpiperazine (mCPP)-induced hypolocomotion[2] and to attenuate haloperidol-induced catalepsy.[1]

The drug was under development by GlaxoSmithKline for the treatment of major depressive disorder and anxiety disorders.[4] It reached the preclinical research phase of development.[4] However, development of the drug was discontinued.[4]

See also

References

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