40S ribosomal protein S3a

40S ribosomal protein S3a is a protein that in humans is encoded by the RPS3A gene.^[5][6][7]

RPS3A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 5FLX, 4D61, 4D5L, 5A2Q, 4UJD, 4UJE, 4UJC
Identifiers
Aliases	RPS3A, FTE1, MFTL, S3A, ribosomal protein S3A
External IDs	OMIM: 180478; MGI: 1202063; HomoloGene: 133575; GeneCards: RPS3A; OMA:RPS3A - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q31.3 Start 151,099,624 bp[1] End 151,104,642 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F1 Start 86,045,247 bp[2] End 86,050,009 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence left ovary Achilles tendon ventricular zone canal of the cervix right ovary lymph node ectocervix body of uterus endometrium Top expressed in ovary ventricular zone uterus thymus ganglionic eminence epiblast embryo esophagus spleen bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding structural constituent of ribosome mRNA 5'-UTR binding Cellular component cytoplasm ribosome focal adhesion intracellular anatomical structure nucleolus extracellular exosome nucleus nucleoplasm extracellular matrix endoplasmic reticulum cytosol cytosolic small ribosomal subunit synapse ribonucleoprotein complex Biological process cell differentiation viral transcription negative regulation of apoptotic process SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6189 20091 Ensembl ENSG00000145425 ENSMUSG00000028081 UniProt P61247 P97351 RefSeq (mRNA) NM_001267699 NM_001006 NM_016959 RefSeq (protein) NP_000997 NP_001254628 NP_058655 Location (UCSC) Chr 4: 151.1 – 151.1 Mb Chr 3: 86.05 – 86.05 Mb PubMed search [3] [4]
Wikidata
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Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. Transcript variants utilizing alternative transcription start sites have been described. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

Interactions

RPS3A has been shown to interact with DNA damage-inducible transcript 3.^[8]