40S ribosomal protein S24

40S ribosomal protein S24 is a protein that in humans is encoded by the RPS24 gene.^[5][6][7]

RPS24
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 4D61, 4D5L, 4UJD, 4UJE, 4UJC
Identifiers
Aliases	RPS24, DBA3, S24, ribosomal protein S24, eS24
External IDs	OMIM: 602412; MGI: 98147; HomoloGene: 68148; GeneCards: RPS24; OMA:RPS24 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.3 Start 78,033,760 bp[1] End 78,056,813 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 24,537,193 bp[2] End 24,547,027 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon ganglionic eminence cartilage tissue caput epididymis lactiferous duct mucosa of paranasal sinus urethra tail of epididymis ventricular zone corpus epididymis Top expressed in ventricular zone embryo embryo genital tubercle yolk sac lip tail of embryo dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome translation initiation factor binding RNA binding Cellular component cytosol ribosome membrane intracellular anatomical structure small ribosomal subunit nucleus nucleoplasm cytosolic small ribosomal subunit Biological process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) viral transcription SRP-dependent cotranslational protein targeting to membrane erythrocyte homeostasis translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ribosomal small subunit biogenesis protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6229 20088 Ensembl ENSG00000138326 ENSMUSG00000025290 UniProt P62847 P62849 RefSeq (mRNA) NM_001026 NM_001142282 NM_001142283 NM_001142284 NM_001142285 NM_033022 NM_011297 NM_207634 NM_207635 NM_001360584 NM_001360585 NM_001360586 RefSeq (protein) NP_001017 NP_001135754 NP_001135755 NP_001135756 NP_001135757 NP_148982 NP_035427 NP_997517 NP_997518 NP_001347513 NP_001347514 NP_001347515 Location (UCSC) Chr 10: 78.03 – 78.06 Mb Chr 14: 24.54 – 24.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000138326 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025290 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jones AM, Marzella R, Rocchi M, Hewitt JE (Mar 1997). "Mapping of the human ribosomal small subunit protein gene RPS24 to the chromosome 10q22-q23 boundary". Genomics. 39 (1): 121–2. doi:10.1006/geno.1996.4442. PMID 9027498.
6. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
7. "Entrez Gene: RPS24 ribosomal protein S24".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Huang RT, Li DR, Wei J, et al. (1992). "Isolation and identification of hepatitis E virus in Xinjiang, China". J. Gen. Virol. 73 (5): 1143–8. doi:10.1099/0022-1317-73-5-1143. PMID 1588318.
• Brown SJ, Jewell A, Maki CG, Roufa DJ (1990). "A cDNA encoding human ribosomal protein S24". Gene. 91 (2): 293–6. doi:10.1016/0378-1119(90)90103-X. PMID 2210388.
• Xu WB, Roufa DJ (1996). "The gene encoding human ribosomal protein S24 and tissue-specific expression of differentially spliced mRNAs". Gene. 169 (2): 257–62. doi:10.1016/0378-1119(96)88652-5. PMID 8647458.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: Native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.