60S ribosomal protein L9

60S ribosomal protein L9 is a protein that in humans is encoded by the RPL9 gene.^[5][6][7]

RPL9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CQL, 4UG0, 4V6X, 5AJ0, 3J92, 4UJC, 3J7P, 4UJE, 3J7Q, 3J7R, 4D67, 4UJD, 4V5Z, 4D5Y, 3J7O
Identifiers
Aliases	RPL9, L9, NPC-A-16, ribosomal protein L9
External IDs	OMIM: 603686; MGI: 1298373; HomoloGene: 90855; GeneCards: RPL9; OMA:RPL9 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p14 Start 39,452,587 bp[1] End 39,458,931 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 C3.1 Start 65,545,707 bp[2] End 65,548,787 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary gastric mucosa Achilles tendon right uterine tube ganglionic eminence lactiferous gland corpus callosum olfactory zone of nasal mucosa gallbladder Top expressed in dentate gyrus of hippocampal formation granule cell ventricular zone blastocyst embryo embryo morula lip superior frontal gyrus primary visual cortex spermatocyte More reference expression data BioGPS n/a
Gene ontology Molecular function rRNA binding protein binding RNA binding structural constituent of ribosome Cellular component cytosol ribosome membrane focal adhesion intracellular anatomical structure cytosolic large ribosomal subunit nucleus extracellular matrix Biological process cytoplasmic translation protein biosynthesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6133 20005 Ensembl ENSG00000163682 ENSMUSG00000047215 UniProt P32969 P51410 RefSeq (mRNA) NM_000661 NM_001024921 NM_011292 RefSeq (protein) NP_000652 NP_001020092 NP_035422 Location (UCSC) Chr 4: 39.45 – 39.46 Mb Chr 5: 65.55 – 65.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000163682 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000047215 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mazuruk K, Schoen TJ, Chader GJ, Iwata T, Rodriguez IR (Apr 1996). "Structural organization and chromosomal localization of the human ribosomal protein L9 gene". Biochim Biophys Acta. 1305 (3): 151–62. doi:10.1016/0167-4781(95)00201-4. PMID 8597601.
6. Hori N, Murakawa K, Matoba R, Fukushima A, Okubo K, Matsubara K (Nov 1993). "A new human ribosomal protein sequence, homologue of rat L9". Nucleic Acids Res. 21 (18): 4395. doi:10.1093/nar/21.18.4395. PMC 310081. PMID 8415001.
7. "Entrez Gene: RPL9 ribosomal protein L9".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human 60S ribosomal protein L9