60S ribosomal protein L7a

60S ribosomal protein L7a is a protein that in humans is encoded by the RPL7A gene.^[5][6][7]

RPL7A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL7A, L7A, SURF3, TRUP, ribosomal protein L7a
External IDs	OMIM: 185640; MGI: 1353472; HomoloGene: 105462; GeneCards: RPL7A; OMA:RPL7A - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.2 Start 133,348,218 bp[1] End 133,351,426 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 19.1 cM Start 26,800,776 bp[2] End 26,803,330 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad left ovary islet of Langerhans right uterine tube left adrenal cortex right ovary right adrenal gland right adrenal cortex smooth muscle tissue pituitary gland Top expressed in epiblast ganglionic eminence ventricular zone uterus embryo embryo ovary esophagus lip lens More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome protein binding cadherin binding RNA binding Cellular component cytoplasm cytosol ribosome membrane focal adhesion nucleolus cytosolic large ribosomal subunit extracellular exosome nucleus polysomal ribosome ribonucleoprotein complex Biological process ribosome biogenesis viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing maturation of LSU-rRNA protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6130 27176 Ensembl ENSG00000280858 ENSG00000148303 ENSMUSG00000062647 UniProt P62424 P12970 RefSeq (mRNA) NM_000972 NM_013721 RefSeq (protein) NP_000963 NP_038749 Location (UCSC) Chr 9: 133.35 – 133.35 Mb Chr 2: 26.8 – 26.8 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

References

1. ENSG00000148303 GRCh38: Ensembl release 89: ENSG00000280858, ENSG00000148303 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062647 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ziemiecki A, Muller RG, Fu XC, Hynes NE, Kozma S (Feb 1990). "Oncogenic activation of the human trk proto-oncogene by recombination with the ribosomal large subunit protein L7a". EMBO J. 9 (1): 191–6. doi:10.1002/j.1460-2075.1990.tb08095.x. PMC 551645. PMID 2403926.
6. Kozma SC, Redmond SM, Fu XC, Saurer SM, Groner B, Hynes NE (May 1988). "Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences". EMBO J. 7 (1): 147–54. doi:10.1002/j.1460-2075.1988.tb02794.x. PMC 454232. PMID 2966065.
7. "Entrez Gene: RPL7A ribosomal protein L7a".

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Colombo P, Fried M (1992). "Functional elements of the ribosomal protein L7a (rpL7a) gene promoter region and their conservation between mammals and birds". Nucleic Acids Res. 20 (13): 3367–73. doi:10.1093/nar/20.13.3367. PMC 312491. PMID 1630908.
• Ben-Ishai R, Scharf R, Sharon R, Kapten I (1990). "A human cellular sequence implicated in trk oncogene activation is DNA damage inducible". Proc. Natl. Acad. Sci. U.S.A. 87 (16): 6039–43. Bibcode:1990PNAS...87.6039B. doi:10.1073/pnas.87.16.6039. PMC 54467. PMID 1696715.
• Colombo P, Yon J, Fried M (1992). "The organization and expression of the human L7a ribosomal protein gene". Biochim. Biophys. Acta. 1129 (1): 93–5. doi:10.1016/0167-4781(91)90218-b. PMID 1756182.
• Burris TP, Nawaz Z, Tsai MJ, O'Malley BW (1995). "A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9525–9. Bibcode:1995PNAS...92.9525B. doi:10.1073/pnas.92.21.9525. PMC 40834. PMID 7568167.
• Qu LH, Henry Y, Nicoloso M, et al. (1995). "U24, a novel intron-encoded small nucleolar RNA with two 12 nt long, phylogenetically conserved complementarities to 28S rRNA". Nucleic Acids Res. 23 (14): 2669–76. doi:10.1093/nar/23.14.2669. PMC 307091. PMID 7651828.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Seshadri T, Uzman JA, Oshima J, Campisi J (1993). "Identification of a transcript that is down-regulated in senescent human fibroblasts. Cloning, sequence analysis, and regulation of the human L7 ribosomal protein gene". J. Biol. Chem. 268 (25): 18474–80. doi:10.1016/S0021-9258(17)46650-6. PMID 8360149.
• De Falco S, Russo G, Angiolillo A, Pietropaolo C (1993). "Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene". Gene. 126 (2): 227–35. doi:10.1016/0378-1119(93)90371-9. PMID 8482538.
• Yon J, Jones T, Garson K, et al. (1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Hum. Mol. Genet. 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID 8499913.
• Nicoloso M, Qu LH, Michot B, Bachellerie JP (1996). "Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs". J. Mol. Biol. 260 (2): 178–95. doi:10.1006/jmbi.1996.0391. PMID 8764399.
• Mor O, Duhig T, Fried M (1996). "A high frequency polymorphism in the candidate region for tuberous sclerosis 1 (TSC1) at 9q34". Ann. Hum. Genet. 60 (Pt 3): 259–60. doi:10.1111/j.1469-1809.1996.tb00429.x. PMID 8800442. S2CID 31900112.
• Russo G, Ricciardelli G, Pietropaolo C (1997). "Different domains cooperate to target the human ribosomal L7a protein to the nucleus and to the nucleoli". J. Biol. Chem. 272 (8): 5229–35. doi:10.1074/jbc.272.8.5229. PMID 9030593.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Gilley J, Fried M (1998). "Evolution of U24 and U36 snoRNAs encoded within introns of vertebrate rpL7a gene homologs: unique features of mammalian U36 variants". DNA Cell Biol. 17 (7): 591–602. doi:10.1089/dna.1998.17.591. PMID 9703018.
• Lalli E, Ohe K, Hindelang C, Sassone-Corsi P (2000). "Orphan receptor DAX-1 is a shuttling RNA binding protein associated with polyribosomes via mRNA". Mol. Cell. Biol. 20 (13): 4910–21. doi:10.1128/MCB.20.13.4910-4921.2000. PMC 85942. PMID 10848616.