QRFP

RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.^[5]

QRFP
Identifiers
Aliases	QRFP, 26RFa, P518, pyroglutamylated RFamide peptide
External IDs	OMIM: 609795; MGI: 3630329; HomoloGene: 52341; GeneCards: QRFP; OMA:QRFP - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.12 Start 130,892,707 bp[1] End 130,896,812 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 B Start 31,696,178 bp[2] End 31,700,592 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad mucosa of transverse colon muscle layer of sigmoid colon stromal cell of endometrium popliteal artery tibial arteries sural nerve left coronary artery Descending thoracic aorta Top expressed in embryo islet of Langerhans white adipose tissue spermatocyte adrenal gland duodenum lip spleen Hypothalamus uterus More reference expression data BioGPS n/a
Gene ontology Molecular function orexigenic neuropeptide QRFP receptor binding neuropeptide hormone activity Cellular component extracellular region cellular component Biological process grooming behavior positive regulation of blood pressure neuropeptide signaling pathway regulation of feeding behavior locomotory behavior regulation of signaling receptor activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 347148 227717 Ensembl ENSG00000188710 ENSMUSG00000043102 UniProt P83859 Q8CE23 RefSeq (mRNA) NM_198180 NM_183424 RefSeq (protein) NP_937823 NP_906269 Location (UCSC) Chr 9: 130.89 – 130.9 Mb Chr 2: 31.7 – 31.7 Mb PubMed search [3] [4]
Wikidata
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The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.^[6] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.^[7]