QRFP

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

QRFP

RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.[5]

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QRFP
Identifiers
AliasesQRFP, 26RFa, P518, pyroglutamylated RFamide peptide
External IDsOMIM: 609795; MGI: 3630329; HomoloGene: 52341; GeneCards: QRFP; OMA:QRFP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198180

NM_183424

RefSeq (protein)

NP_937823

NP_906269

Location (UCSC)Chr 9: 130.89 – 130.9 MbChr 2: 31.7 – 31.7 Mb
PubMed search[3][4]
Wikidata
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The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.[6] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.[7]

References

Further reading

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