Plague or The Plague may refer to:
- Plague (disease), (commonly referred to as bubonic plague or black death), caused by infectious bacteria Yersinia pestis
- An epidemic of infectious disease (medical or agricultural)
- A pandemic caused by such a disease
- A swarm of pest insects such as locusts
- Plague, collective noun for common grackles
Games
- Corrupted Blood incident, a virtual plague that occurred in the video game World of Warcraft
- Plague Inc., a strategy game for smartphones and tablets by Ndemic Creations
- Plague!, a card game about the Black Plague in England
- Plague of Shadows (Plague Knight), a character and DLC gamemode for Shovel Knight
- The Plague, a playable killer character of Babylonian origin from the asymmetrical-survival horror Dead by Daylight
- Plagues of Egypt, the 10 calamities that God inflicted on Egypt in the book of Exodus
- The seven plagues poured out from seven bowls in Revelation 15:5-16:21
- Capacitor plague, a condition afflicting computer motherboards in which capacitors fail