Petrescu is a patronymic family name common in Romania, meaning "son of Petre". Notable people with this surname include:
- Anca Petrescu, architect and politician
- Arcadie Petrescu, neurologist
- Barbu Petrescu, mayor of Bucharest (1989–1990)
- Camil Petrescu, writer
- Cezar Petrescu, writer
- Constantin Titel Petrescu, social-democratic politician
- Costin Petrescu, painter
- Costin Petrescu, rock music drummer
- Cristian Petrescu, politician
- Dan Petrescu (disambiguation)
- Daniela Petrescu, long-distance runner
- Dimitrie Petrescu-Stelaru, writer
- Dumitru Petrescu, communist politician
- Emil Petrescu, mayor of Bucharest (1914–1916; 1918)
- Emilia Petrescu, soprano
- Ghenadie Petrescu, deposed Romanian Metropolitan Patriarch
- Gică Petrescu, singer
- Horia Petra-Petrescu, literary critic
- Marian Petrescu (born 1970), Romanian jazz pianist
- Nicolae Petrescu (1886–1954), philosopher and sociologist
- Nicolae Petrescu-Comnen, diplomat and politician
- Nicolae Petrescu Găină, painter
- Teodosie Petrescu, Archbishop of Tomi
- Virgil Petrescu, politician
- Zaharia Petrescu, physician
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It is also the maiden name of: