Plakophilin-4

Plakophilin-4 is a protein that in humans is encoded by the PKP4 gene.^[5][6][7]

PKP4
Identifiers
Aliases	PKP4, p0071, plakophilin 4
External IDs	OMIM: 604276; MGI: 109281; HomoloGene: 2689; GeneCards: PKP4; OMA:PKP4 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q24.1 Start 158,456,952 bp[1] End 158,682,879 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 C1.1 Start 59,160,850 bp[2] End 59,355,208 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment inferior ganglion of vagus nerve internal globus pallidus corpus callosum pars reticulata subthalamic nucleus caput epididymis amygdala putamen middle frontal gyrus Top expressed in ciliary body iris substantia nigra Region I of hippocampus proper tunica media of zone of aorta deep cerebellar nuclei ascending aorta motor neuron amygdala submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cadherin binding Cellular component cytoplasm spindle pole membrane postsynaptic density cell-cell contact zone cell-cell junction spindle desmosome cell junction midbody spindle midzone perinuclear region of cytoplasm cytoplasmic side of plasma membrane mitotic spindle cytoskeleton cornified envelope plasma membrane nucleus Biological process cell-cell signaling positive regulation of cytokinesis positive regulation of GTPase activity regulation of cell adhesion cell adhesion cell-cell junction assembly keratinization cornification cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8502 227937 Ensembl ENSG00000144283 ENSMUSG00000026991 UniProt Q99569 Q68FH0 RefSeq (mRNA) NM_001005476 NM_001304969 NM_001304970 NM_001304971 NM_003628 NM_001377218 NM_001377219 NM_001377220 NM_001377221 NM_001377222 NM_001377223 NM_001377224 NM_001377225 NM_001377226 NM_026361 NM_175464 NM_001362990 NM_001362991 NM_001362992 NM_001362993 NM_001362994 NM_001362995 NM_001362996 NM_001362997 NM_001362998 NM_001362999 RefSeq (protein) NP_001005476 NP_001291898 NP_001291899 NP_001291900 NP_003619 NP_001364147 NP_001364148 NP_001364149 NP_001364150 NP_001364151 NP_001364152 NP_001364153 NP_001364154 NP_001364155 NP_080637 NP_780673 NP_001349919 NP_001349920 NP_001349921 NP_001349922 NP_001349923 NP_001349924 NP_001349925 NP_001349926 NP_001349927 NP_001349928 Location (UCSC) Chr 2: 158.46 – 158.68 Mb Chr 2: 59.16 – 59.36 Mb PubMed search [3] [4]
Wikidata
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Function

Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms.^[7]

Interactions

PKP4 has been shown to interact with:

• Erbin,^[8][9][10]
• PDZD2,^[11][12] and
• PSEN1.^[13]

References

1. GRCh38: Ensembl release 89: ENSG00000144283 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026991 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Paffenholz R, Franke WW (December 1997). "Identification and localization of a neurally expressed member of the plakoglobin/armadillo multigene family". Differentiation. 61 (5): 293–304. doi:10.1046/j.1432-0436.1997.6150293.x. PMID 9342840.
6. Hatzfeld M, Nachtsheim C (May 1997). "Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins". J Cell Sci. 109 (11): 2767–78. doi:10.1242/jcs.109.11.2767. PMID 8937994.
7. "Entrez Gene: PKP4 plakophilin 4".
8. Izawa I, Nishizawa M, Tomono Y, Ohtakara K, Takahashi T, Inagaki M (May 2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells". Genes Cells. 7 (5): 475–85. doi:10.1046/j.1365-2443.2002.00533.x. PMID 12047349. S2CID 12598418.
9. Jaulin-Bastard F, Arsanto JP, Le Bivic A, Navarro C, Vély F, Saito H, Marchetto S, Hatzfeld M, Santoni MJ, Birnbaum D, Borg JP (January 2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells". J. Biol. Chem. 277 (4): 2869–75. doi:10.1074/jbc.M109652200. PMID 11711544.
10. Laura RP, Witt AS, Held HA, Gerstner R, Deshayes K, Koehler MF, Kosik KS, Sidhu SS, Lasky LA (April 2002). "The Erbin PDZ domain binds with high affinity and specificity to the carboxyl termini of delta-catenin and ARVCF". J. Biol. Chem. 277 (15): 12906–14. doi:10.1074/jbc.M200818200. PMID 11821434.
11. Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (September 2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID 10896674.
12. Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (October 2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene. 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826.
13. Stahl B, Diehlmann A, Südhof TC (April 1999). "Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071". J. Biol. Chem. 274 (14): 9141–8. doi:10.1074/jbc.274.14.9141. PMID 10092585.

Further reading

• Keil R, Wolf A, Hüttelmaier S, Hatzfeld M (2007). "Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin". Cell Cycle. 6 (2): 122–7. doi:10.4161/cc.6.2.3741. PMID 17264675.
• Bonné S, van Hengel J, van Roy F (1998). "Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily". Genomics. 51 (3): 452–4. doi:10.1006/geno.1998.5398. PMID 9721216.
• Levesque G, Yu G, Nishimura M, Zhang DM, Levesque L, Yu H, Xu D, Liang Y, Rogaeva E, Ikeda M, Duthie M, Murgolo N, Wang L, VanderVere P, Bayne ML, Strader CD, Rommens JM, Fraser PE, St George-Hyslop P (1999). "Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin". J. Neurochem. 72 (3): 999–1008. doi:10.1046/j.1471-4159.1999.0720999.x. PMID 10037471. S2CID 36124450.
• Stahl B, Diehlmann A, Südhof TC (1999). "Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071". J. Biol. Chem. 274 (14): 9141–8. doi:10.1074/jbc.274.14.9141. PMID 10092585.
• Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y (2000). "PAPIN. A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin and p0071". J. Biol. Chem. 275 (38): 29875–80. doi:10.1074/jbc.M005384200. PMID 10896674.
• Schröder R, van der Ven PF, Warlo I, Schumann H, Fürst DO, Blümcke I, Schmidt MC, Hatzfeld M (2001). "p0071, a member of the armadillo multigene family, is a constituent of sarcomeric I-bands in human skeletal muscle". J. Muscle Res. Cell. Motil. 21 (6): 577–86. doi:10.1023/A:1026587530656. PMID 11206135. S2CID 1342967.
• Jaulin-Bastard F, Arsanto JP, Le Bivic A, Navarro C, Vély F, Saito H, Marchetto S, Hatzfeld M, Santoni MJ, Birnbaum D, Borg JP (2002). "Interaction between Erbin and a Catenin-related protein in epithelial cells". J. Biol. Chem. 277 (4): 2869–75. doi:10.1074/jbc.M109652200. PMID 11711544.
• Izawa I, Nishizawa M, Tomono Y, Ohtakara K, Takahashi T, Inagaki M (2002). "ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells". Genes Cells. 7 (5): 475–85. doi:10.1046/j.1365-2443.2002.00533.x. PMID 12047349. S2CID 12598418.
• Ohno H, Hirabayashi S, Iizuka T, Ohnishi H, Fujita T, Hata Y (2002). "Localization of p0071-interacting proteins, plakophilin-related armadillo-repeat protein-interacting protein (PAPIN) and ERBIN, in epithelial cells". Oncogene. 21 (46): 7042–9. doi:10.1038/sj.onc.1205852. PMID 12370826.
• Calkins CC, Hoepner BL, Law CM, Novak MR, Setzer SV, Hatzfeld M, Kowalczyk AP (2003). "The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding protein". J. Biol. Chem. 278 (3): 1774–83. doi:10.1074/jbc.M205693200. PMID 12426320.
• Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, Sauer K, Brock A, Horn DM, Schultz PG, Peters EC (2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proc. Natl. Acad. Sci. U.S.A. 100 (2): 443–8. Bibcode:2003PNAS..100..443S. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.
• Hatzfeld M, Green KJ, Sauter H (2003). "Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains". J. Cell Sci. 116 (Pt 7): 1219–33. doi:10.1242/jcs.00275. PMID 12615965.
• Setzer SV, Calkins CC, Garner J, Summers S, Green KJ, Kowalczyk AP (2004). "Comparative analysis of armadillo family proteins in the regulation of a431 epithelial cell junction assembly, adhesion and migration". J. Invest. Dermatol. 123 (3): 426–33. doi:10.1111/j.0022-202X.2004.23319.x. PMID 15304078.
• Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, White FM (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Tao WA, Wollscheid B, O'Brien R, Eng JK, Li XJ, Bodenmiller B, Watts JD, Hood L, Aebersold R (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.