PH-797804

PH-797804
Identifiers
	IUPAC name 3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxopyridin-1-yl]-N,4-dimethylbenzamide;
CAS Number	586379-66-0;
PubChem CID	22049997;
IUPHAR/BPS	7818;
DrugBank	DB07941;
ChemSpider	10796940;
UNII	SI09I1V827;
ChEBI	CHEBI:82715;
ChEMBL	ChEMBL1088751;
CompTox Dashboard (EPA)	DTXSID70207342 ;
Chemical and physical data
Formula	C22H19BrF2N2O3
Molar mass	477.306 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C=C(C=C1)C(=O)NC)N2C(=CC(=C(C2=O)Br)OCC3=C(C=C(C=C3)F)F)C;
	InChI InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28); Key:KCAJXIDMCNPGHZ-UHFFFAOYSA-N;

PH-797804 is a drug which acts as a selective inhibitor of the enzyme p38 mitogen-activated protein kinase (p38 MAPK). It has antiinflammatory effects and has been researched for the treatment of inflammatory lung conditions such as chronic obstructive pulmonary disease and COVID-19. While it has not been adopted for clinical use, it remains widely used in research.^[1]^[2]^[3]^[4]^[5]

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See also