P2RY2

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.^[5][6]

P2RY2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z8E
Identifiers
Aliases	P2RY2, HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R, purinergic receptor P2Y2
External IDs	OMIM: 600041; MGI: 105107; HomoloGene: 1927; GeneCards: P2RY2; OMA:P2RY2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 73,218,281 bp[1] End 73,242,427 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 100,645,775 bp[2] End 100,662,073 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle Skeletal muscle tissue of rectus abdominis mucosa of esophagus vastus lateralis muscle biceps brachii Skeletal muscle tissue of biceps brachii deltoid muscle gingival epithelium triceps brachii muscle Top expressed in muscle of thigh extensor digitorum longus muscle corneal stroma plantaris muscle granulocyte soleus muscle interventricular septum skeletal muscle tissue digastric muscle thoracic diaphragm More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity G protein-coupled purinergic nucleotide receptor activity signal transducer activity signaling receptor activity Cellular component integral component of membrane membrane integral component of plasma membrane plasma membrane Biological process G protein-coupled purinergic nucleotide receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway cellular ion homeostasis positive regulation of mucus secretion signal transduction blood vessel diameter maintenance G protein-coupled receptor signaling pathway cellular response to ATP Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5029 18442 Ensembl ENSG00000175591 ENSMUSG00000032860 UniProt P41231 P35383 RefSeq (mRNA) NM_002564 NM_176071 NM_176072 NM_008773 NM_001302346 NM_001302347 RefSeq (protein) NP_002555 NP_788085 NP_788086 NP_001289275 NP_001289276 NP_032799 Location (UCSC) Chr 11: 73.22 – 73.24 Mb Chr 7: 100.65 – 100.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The product of this gene, P2Y₂ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.^[7]

See also

• P2Y receptor
• Denufosol, a P2Y₂ agonist

References

1. GRCh38: Ensembl release 89: ENSG00000175591 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032860 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT (May 1994). "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy". Proc Natl Acad Sci USA. 91 (8): 3275–9. Bibcode:1994PNAS...91.3275P. doi:10.1073/pnas.91.8.3275. PMC 43559. PMID 8159738.
6. Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ (Nov 1997). "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family". Genomics. 44 (1): 127–30. doi:10.1006/geno.1997.4841. PMID 9286708.
7. "Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2".

Further reading

• Tokuyama Y, Hara M, Jones EM, et al. (1995). "Cloning of rat and mouse P2Y purinoceptors". Biochem. Biophys. Res. Commun. 211 (1): 211–8. doi:10.1006/bbrc.1995.1798. PMID 7779087.
• Parr CE, Sullivan DM, Paradiso AM, et al. (1995). "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 13067. doi:10.1073/pnas.91.26.13067. PMC 45582. PMID 7809171.
• Erb L, Lustig KD, Sullivan DM, et al. (1993). "Functional expression and photoaffinity labeling of a cloned P2U purinergic receptor". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10449–53. Bibcode:1993PNAS...9010449E. doi:10.1073/pnas.90.22.10449. PMC 47794. PMID 8248130.
• Dasari VR, Sandhu AK, Mills DC, et al. (1996). "Mapping of the P2U purinergic receptor gene to human chromosome 11q 13.5-14.1". Somat. Cell Mol. Genet. 22 (1): 75–9. doi:10.1007/BF02374378. PMID 8643996. S2CID 6509435.
• Sullivan DM, Erb L, Anglade E, et al. (1997). "Identification and characterization of P2Y2 nucleotide receptors in human retinal pigment epithelial cells". J. Neurosci. Res. 49 (1): 43–52. doi:10.1002/(SICI)1097-4547(19970701)49:1<43::AID-JNR5>3.0.CO;2-D. PMID 9211988. S2CID 21044840.
• Bogdanov Y, Rubino A, Burnstock G (1998). "Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart". Life Sci. 62 (8): 697–703. doi:10.1016/S0024-3205(97)01168-5. PMID 9489506.
• Jin J, Dasari VR, Sistare FD, Kunapuli SP (1998). "Distribution of P2Y receptor subtypes on haematopoietic cells". Br. J. Pharmacol. 123 (5): 789–94. doi:10.1038/sj.bjp.0701665. PMC 1565225. PMID 9535005.
• Tai CJ, Kang SK, Cheng KW, et al. (2000). "Expression and regulation of P2U-purinergic receptor in human granulosa-luteal cells". J. Clin. Endocrinol. Metab. 85 (4): 1591–7. doi:10.1210/jcem.85.4.6558. PMID 10770202.
• Erb L, Liu J, Ockerhausen J, et al. (2001). "An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction". J. Cell Biol. 153 (3): 491–501. doi:10.1083/jcb.153.3.491. PMC 2190579. PMID 11331301.
• Moore DJ, Chambers JK, Wahlin JP, et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study". Biochim. Biophys. Acta. 1521 (1–3): 107–19. doi:10.1016/S0167-4781(01)00291-3. PMID 11690642.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Burrell HE, Bowler WB, Gallagher JA, Sharpe GR (2003). "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors". J. Invest. Dermatol. 120 (3): 440–7. doi:10.1046/j.1523-1747.2003.12050.x. PMID 12603858.
• Schafer R, Sedehizade F, Welte T, Reiser G (2003). "ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (2): L376–85. doi:10.1152/ajplung.00447.2002. PMID 12691958. S2CID 108677.
• Seye CI, Yu N, Jain R, et al. (2003). "The P2Y2 nucleotide receptor mediates UTP-induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells". J. Biol. Chem. 278 (27): 24960–5. doi:10.1074/jbc.M301439200. PMID 12714597.
• Greig AV, Linge C, Terenghi G, et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes". J. Invest. Dermatol. 120 (6): 1007–15. doi:10.1046/j.1523-1747.2003.12261.x. PMID 12787128.
• Greig AV, Linge C, Healy V, et al. (2003). "Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells". J. Invest. Dermatol. 121 (2): 315–27. doi:10.1046/j.1523-1747.2003.12379.x. PMID 12880424.
• Meshki J, Tuluc F, Bredetean O, et al. (2004). "Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor". Am. J. Physiol., Cell Physiol. 286 (2): C264–71. doi:10.1152/ajpcell.00287.2003. PMID 14613890. S2CID 21388137.
• Haserück N, Erl W, Pandey D, et al. (2004). "The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors". Blood. 103 (7): 2585–92. doi:10.1182/blood-2003-04-1127. PMID 14645014.

External links

• "P2Y Receptors: P2Y₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.