P2RY1

P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.^[5]

P2RY1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XNV, 4XNW
Identifiers
Aliases	P2RY1, P2Y1, purinergic receptor P2Y1, SARCC
External IDs	OMIM: 601167; MGI: 105049; HomoloGene: 1926; GeneCards: P2RY1; OMA:P2RY1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.2 Start 152,835,131 bp[1] End 152,841,439 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 E1 Start 60,910,216 bp[2] End 60,916,403 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium endothelial cell oral cavity internal globus pallidus visceral pleura amniotic fluid placenta nucleus accumbens tibia lower lobe of lung Top expressed in lumbar spinal ganglion duodenum islet of Langerhans granulocyte jejunum esophagus lip muscle of thigh embryo right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function A1 adenosine receptor binding G protein-coupled receptor activity scaffold protein binding ADP binding G protein-coupled purinergic nucleotide receptor activity signal transducer activity protein binding protein heterodimerization activity G protein-coupled ATP receptor activity ATP binding nucleotide binding signaling receptor activity Cellular component cell body integral component of membrane postsynaptic membrane membrane plasma membrane integral component of plasma membrane cell surface dendrite basolateral plasma membrane apical plasma membrane mitochondrion postsynaptic density glutamatergic synapse integral component of presynaptic active zone membrane cilium Biological process hemostasis cellular response to organic cyclic compound G protein-coupled adenosine receptor signaling pathway positive regulation of protein phosphorylation adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway eating behavior positive regulation of cytosolic calcium ion concentration response to mechanical stimulus ageing regulation of signaling receptor activity negative regulation of norepinephrine secretion signal transduction involved in regulation of gene expression wound healing G protein-coupled purinergic nucleotide receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway cell surface receptor signaling pathway positive regulation of inositol trisphosphate biosynthetic process negative regulation of binding positive regulation of ion transport positive regulation of ERK1 and ERK2 cascade sensory perception of pain response to growth factor positive regulation of penile erection protein localization to plasma membrane positive regulation of hormone secretion relaxation of muscle positive regulation of transcription by RNA polymerase II glial cell migration signal transduction blood coagulation platelet activation blood vessel diameter maintenance G protein-coupled receptor signaling pathway regulation of cell shape cellular response to ATP cellular response to purine-containing compound regulation of presynaptic cytosolic calcium ion concentration regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5028 18441 Ensembl ENSG00000169860 ENSMUSG00000027765 UniProt P47900 P49650 RefSeq (mRNA) NM_002563 NM_001282016 NM_008772 RefSeq (protein) NP_002554 NP_001268945 NP_032798 Location (UCSC) Chr 3: 152.84 – 152.84 Mb Chr 3: 60.91 – 60.92 Mb PubMed search [3] [4]
Wikidata
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Function

The product of this gene, P2Y₁ belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.^[6]

See also

• P2Y receptor