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p21 activated kinases (PAKs) are members of a family of enzymes.[1] They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities.
Members include:
- PAK1, regulating cell motility and morphology[2]
- PAK2, possibly playing a role in apoptosis[3]
- PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity[4]
- PAK4, a mediator of filopodia formation[5]
- PAK5, a mediator of filopodia formation[6]
- PAK6, involved in cytoskeleton rearrangement[7]
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