Tachykinin receptor

There are three known mammalian tachykinin receptors termed NK₁, NK₂ and NK₃. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called G_q-coupled).

Tachykinin receptor
Identifiers
Symbol	?
InterPro	IPR001681

tachykinin receptor 1
Identifiers
Symbol	TACR1
Alt. symbols	TAC1R
NCBI gene	6869
HGNC	11526
OMIM	162323
RefSeq	NM_001058
UniProt	P25103
Other data
Locus	Chr. 2 p13.1-p12
Search for Structures Swiss-model Domains InterPro

tachykinin receptor 2
Identifiers
Symbol	TACR2
Alt. symbols	TAC2R, NKNAR
NCBI gene	6865
HGNC	11527
OMIM	162321
RefSeq	NM_001057
UniProt	P21452
Other data
Locus	Chr. 10 q11-q21
Search for Structures Swiss-model Domains InterPro

tachykinin receptor 3
Identifiers
Symbol	TACR3
NCBI gene	6870
HGNC	11528
OMIM	162332
RefSeq	NM_001059
UniProt	P29371
Other data
Locus	Chr. 4 q25
Search for Structures Swiss-model Domains InterPro

Inhibitors of NK-1, known as NK-1 receptor antagonists, can be used as antiemetic agents, such as the drug aprepitant.^[1]

Binding

The genes and receptor ligands are as follows:^[2]

Receptor	Gene	Preferred ligand
NK1	TACR1	substance P
NK2	TACR2	neurokinin A
NK3	TACR3	neurokinin B

(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)

See also

• Substance P
• G protein coupled receptors

References

1. "Aprepitant". NICE. Retrieved 2020-05-10.
2. Maggi CA (September 1995). "The mammalian tachykinin receptors". General Pharmacology. 26 (5): 911–44. doi:10.1016/0306-3623(94)00292-U. PMID 7557266.

External links

• "Tachykinin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Tachykinin+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)