Nucleoporin 205

Nucleoporin 205 (Nup205) is a protein that in humans is encoded by the NUP205 gene.^[5][6][7]

NUP205
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 5IJN, 5IJO
Identifiers
Aliases	NUP205, C7orf14, NPHS13, nucleoporin 205kDa, nucleoporin 205
External IDs	OMIM: 614352; MGI: 2141625; HomoloGene: 45971; GeneCards: NUP205; OMA:NUP205 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q33 Start 135,557,917 bp[1] End 135,648,757 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B1 Start 35,154,356 bp[2] End 35,224,531 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence secondary oocyte anterior pituitary gonad skin of abdomen ectocervix skin of leg mucosa of transverse colon left uterine tube Top expressed in spermatocyte hand primitive streak spermatid seminiferous tubule maxillary prominence abdominal wall mandibular prominence epiblast endothelial cell of lymphatic vessel More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of nuclear pore protein binding Cellular component nuclear membrane nuclear envelope membrane nuclear periphery nuclear pore inner ring nuclear pore nucleus host cell Biological process mRNA transport nuclear pore complex assembly viral transcription protein sumoylation mitotic nuclear membrane disassembly nucleocytoplasmic transport regulation of cellular response to heat protein transport viral process intracellular transport of virus tRNA export from nucleus mRNA export from nucleus regulation of gene silencing by miRNA regulation of glycolytic process transport nuclear pore organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23165 70699 Ensembl ENSG00000155561 ENSMUSG00000038759 UniProt Q92621 n/a RefSeq (mRNA) NM_015135 NM_001329434 NM_027513 RefSeq (protein) NP_001316363 NP_055950 n/a Location (UCSC) Chr 7: 135.56 – 135.65 Mb Chr 6: 35.15 – 35.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPC's are composed of subcomplexes, and NUP205 is part of one such subcomplex.^[5] It has also been recently shown that Nup205 is required for proper viral gene expression.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000155561 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038759 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NUP205 nucleoporin 205kDa".
6. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
7. Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (October 1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.
8. Lu Y, Kucharski TJ, Gamache I, Blanchette P, Branton PE, Teodoro JG (Nov 2014). "Interaction of adenovirus type 5 E4orf4 with the nuclear pore subunit Nup205 is required for proper viral gene expression". J Virol. 88 (22): 13249–59. doi:10.1128/JVI.00933-14. PMC 4249058. PMID 25210169.

Further reading

• Hawryluk-Gara LA, Shibuya EK, Wozniak RW (2005). "Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex". Mol. Biol. Cell. 16 (5): 2382–94. doi:10.1091/mbc.E04-10-0857. PMC 1087243. PMID 15703211.
• Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell. 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.
• Le Rouzic E, Mousnier A, Rustum C, Stutz F, Hallberg E, Dargemont C, Benichou S (2002). "Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1". J. Biol. Chem. 277 (47): 45091–8. doi:10.1074/jbc.M207439200. PMID 12228227.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Hase ME, Cordes VC (2003). "Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex". Mol. Biol. Cell. 14 (5): 1923–40. doi:10.1091/mbc.E02-09-0620. hdl:11858/00-001M-0000-0028-3D33-F. PMC 165087. PMID 12802065.
• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell. 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.