Nucleoporin 107

Nucleoporin 107 (Nup107) is a protein that in humans is encoded by the NUP107 gene.^[5][6][7]

NUP107
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3CQC, 3CQG, 3I4R, 5A9Q
Identifiers
Aliases	NUP107, NUP84, NPHS11, nucleoporin 107kDa, nucleoporin 107, ODG6, ODG6; GAMOS7
External IDs	OMIM: 607617; MGI: 2143854; HomoloGene: 5555; GeneCards: NUP107; OMA:NUP107 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q15 Start 68,686,951 bp[1] End 68,745,809 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 117,586,526 bp[2] End 117,628,610 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone Achilles tendon embryo ganglionic eminence rectum parietal pleura germinal epithelium gastric mucosa visceral pleura Top expressed in primitive streak tail of embryo oocyte primary oocyte secondary oocyte zygote yolk sac genital tubercle epiblast abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of nuclear pore protein binding Cellular component cytosol centrosome nuclear membrane nuclear periphery membrane nuclear envelope nuclear pore nucleoplasm chromosome nuclear pore outer ring chromosome, centromeric region nucleus kinetochore host cell Biological process mRNA transport nuclear pore complex assembly regulation of transcription, DNA-templated protein import into nucleus viral transcription protein sumoylation mitotic nuclear membrane disassembly regulation of cellular response to heat protein transport posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery viral process tRNA export from nucleus sister chromatid cohesion intracellular transport of virus mRNA export from nucleus female gonad development regulation of gene silencing by miRNA regulation of glycolytic process transport nephron development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57122 103468 Ensembl ENSG00000111581 ENSMUSG00000052798 UniProt P57740 Q8BH74 RefSeq (mRNA) NM_020401 NM_001330192 NM_134010 RefSeq (protein) NP_001317121 NP_065134 NP_598771 Location (UCSC) Chr 12: 68.69 – 68.75 Mb Chr 10: 117.59 – 117.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is an essential component of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[7]

Interactions

NUP107 has been shown to interact with NUP133.^[8][9]

References

1. GRCh38: Ensembl release 89: ENSG00000111581 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052798 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Boehmer T, Enninga J, Dales S, Blobel G, Zhong H (Feb 2003). "Depletion of a single nucleoporin, Nup107, prevents the assembly of a subset of nucleoporins into the nuclear pore complex". Proceedings of the National Academy of Sciences of the United States of America. 100 (3): 981–5. Bibcode:2003PNAS..100..981B. doi:10.1073/pnas.252749899. PMC 298712. PMID 12552102.
6. Walther TC, Alves A, Pickersgill H, Loïodice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V (Apr 2003). "The conserved Nup107-160 complex is critical for nuclear pore complex assembly". Cell. 113 (2): 195–206. doi:10.1016/S0092-8674(03)00235-6. PMID 12705868. S2CID 16449133.
7. "Entrez Gene: NUP107 nucleoporin 107kDa".
8. Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
9. Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". The Journal of Cell Biology. 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC 2150808. PMID 11564755.

Further reading

• Bastos R, Ribas de Pouplana L, Enarson M, Bodoor K, Burke B (Jun 1997). "Nup84, a novel nucleoporin that is associated with CAN/Nup214 on the cytoplasmic face of the nuclear pore complex". The Journal of Cell Biology. 137 (5): 989–1000. doi:10.1083/jcb.137.5.989. PMC 2136229. PMID 9166401.
• Belgareh N, Rabut G, Baï SW, van Overbeek M, Beaudouin J, Daigle N, Zatsepina OV, Pasteau F, Labas V, Fromont-Racine M, Ellenberg J, Doye V (Sep 2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells". The Journal of Cell Biology. 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC 2150808. PMID 11564755.
• Vasu S, Shah S, Orjalo A, Park M, Fischer WH, Forbes DJ (Oct 2001). "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export". The Journal of Cell Biology. 155 (3): 339–54. doi:10.1083/jcb.200108007. PMC 2150853. PMID 11684705.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Walther TC, Askjaer P, Gentzel M, Habermann A, Griffiths G, Wilm M, Mattaj IW, Hetzer M (Aug 2003). "RanGTP mediates nuclear pore complex assembly". Nature. 424 (6949): 689–94. Bibcode:2003Natur.424..689W. doi:10.1038/nature01898. PMID 12894213. S2CID 4423987.
• Loïodice I, Alves A, Rabut G, Van Overbeek M, Ellenberg J, Sibarita JB, Doye V (Jul 2004). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Molecular Biology of the Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
• Krull S, Thyberg J, Björkroth B, Rackwitz HR, Cordes VC (Sep 2004). "Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket". Molecular Biology of the Cell. 15 (9): 4261–77. doi:10.1091/mbc.E04-03-0165. PMC 515357. PMID 15229283.
• Berke IC, Boehmer T, Blobel G, Schwartz TU (Nov 2004). "Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex". The Journal of Cell Biology. 167 (4): 591–7. doi:10.1083/jcb.200408109. PMC 2172596. PMID 15557116.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Orjalo AV, Arnaoutov A, Shen Z, Boyarchuk Y, Zeitlin SG, Fontoura B, Briggs S, Dasso M, Forbes DJ (Sep 2006). "The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly". Molecular Biology of the Cell. 17 (9): 3806–18. doi:10.1091/mbc.E05-11-1061. PMC 1593160. PMID 16807356.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Glavy JS, Krutchinsky AN, Cristea IM, Berke IC, Boehmer T, Blobel G, Chait BT (Mar 2007). "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex". Proceedings of the National Academy of Sciences of the United States of America. 104 (10): 3811–6. Bibcode:2007PNAS..104.3811G. doi:10.1073/pnas.0700058104. PMC 1820666. PMID 17360435.
• Zuccolo M, Alves A, Galy V, Bolhy S, Formstecher E, Racine V, Sibarita JB, Fukagawa T, Shiekhattar R, Yen T, Doye V (Apr 2007). "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions". The EMBO Journal. 26 (7): 1853–64. doi:10.1038/sj.emboj.7601642. PMC 1847668. PMID 17363900.
• Boehmer T, Schwartz TU (Sep 2007). "Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex". Acta Crystallographica Section F. 63 (Pt 9): 816–8. doi:10.1107/S1744309107040523. PMC 2376328. PMID 17768364.