Neurotrophin-4

Neurotrophin-4 (NT-4),^[5] also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene.^[6] It is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase.^[7][8] NT-4 was first discovered and isolated from xenopus and viper in the year 1991 by Finn Hallbook et.al^[9]

NTF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HCF, 1B8M, 1B98
Identifiers
Aliases	NTF4, GLC10, GLC1O, NT-4, NT-4/5, NT-5, NT4, NT5, NTF5, neurotrophin 4
External IDs	OMIM: 162662; MGI: 97381; HomoloGene: 4503; GeneCards: NTF4; OMA:NTF4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 49,061,066 bp[1] End 49,065,076 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 29.3 cM Start 45,063,119 bp[2] End 45,066,603 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle skeletal muscle tissue skin of abdomen muscle of thigh skin of leg gonad prostate mucosa of esophagus gastrocnemius muscle minor salivary glands Top expressed in hand Gonadal ridge molar sternocleidomastoid muscle tibialis anterior muscle upper arm knee joint triceps brachii muscle urothelium vas deferens More reference expression data BioGPS n/a
Gene ontology Molecular function neurotrophin p75 receptor binding signaling receptor binding protein binding growth factor activity Cellular component cytoplasmic vesicle extracellular region extracellular space synaptic vesicle axon dendrite Biological process negative regulation of neuron apoptotic process regulation of neuron differentiation adult locomotory behavior sensory organ boundary specification cell-cell signaling neuron projection morphogenesis innervation negative regulation of cell death long-term memory taste bud development mechanoreceptor differentiation transmembrane receptor protein tyrosine kinase signaling pathway ganglion mother cell fate determination epidermis development regulation of signaling receptor activity activation of phospholipase C activity neurotrophin TRK receptor signaling pathway peripheral nervous system development memory nerve development nerve growth factor signaling pathway modulation of chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4909 78405 Ensembl ENSG00000225950 ENSMUSG00000074121 UniProt P34130 Q80VU4 RefSeq (mRNA) NM_006179 NM_001395489 NM_198190 RefSeq (protein) NP_006170 NP_937833 Location (UCSC) Chr 19: 49.06 – 49.07 Mb Chr 7: 45.06 – 45.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• Tropomyosin receptor kinase B § Agonists

References

1. GRCh38: Ensembl release 89: ENSG00000225950 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074121 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ibáñez CF, Ernfors P, Timmusk T, Ip NY, Arenas E, Yancopoulos GD, Persson H (April 1993). "Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion". Development. 117 (4): 1345–1353. doi:10.1242/dev.117.4.1345. PMID 8404536.
6. "Entrez Gene: neurotrophin 4".
7. Klein R, Lamballe F, Bryant S, Barbacid M (May 1992). "The trkB tyrosine protein kinase is a receptor for neurotrophin-4". Neuron. 8 (5): 947–956. doi:10.1016/0896-6273(92)90209-v. PMID 1375038. S2CID 9772551.
8. Ip NY, Stitt TN, Tapley P, Klein R, Glass DJ, Fandl J, et al. (February 1993). "Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells". Neuron. 10 (2): 137–149. doi:10.1016/0896-6273(93)90306-c. PMID 7679912. S2CID 46072027.
9. Hallböök F, Ibáñez CF, Persson H (May 1991). "Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary". Neuron. 6 (5): 845–858. doi:10.1016/0896-6273(91)90180-8. PMID 2025430. S2CID 17772282.

Further reading

• Childs AJ, Bayne RA, Murray AA, Martins Da Silva SJ, Collins CS, Spears N, Anderson RA (April 2010). "Differential expression and regulation by activin of the neurotrophins BDNF and NT4 during human and mouse ovarian development". Developmental Dynamics. 239 (4): 1211–1219. doi:10.1002/dvdy.22252. PMC 3410523. PMID 20175187.
• Vithana EN, Nongpiur ME, Venkataraman D, Chan SH, Mavinahalli J, Aung T (August 2010). "Identification of a novel mutation in the NTF4 gene that causes primary open-angle glaucoma in a Chinese population". Molecular Vision. 16: 1640–1645. PMC 2927376. PMID 20806036.
• Truzzi F, Marconi A, Lotti R, Dallaglio K, French LE, Hempstead BL, Pincelli C (August 2008). "Neurotrophins and their receptors stimulate melanoma cell proliferation and migration". The Journal of Investigative Dermatology. 128 (8): 2031–2040. doi:10.1038/jid.2008.21. PMID 18305571.
• Harel S, Jin S, Fisch B, Feldberg D, Krissi H, Felz C, et al. (June 2006). "Tyrosine kinase B receptor and its activated neurotrophins in ovaries from human fetuses and adults". Molecular Human Reproduction. 12 (6): 357–365. doi:10.1093/molehr/gal033. PMID 16648150.
• Ribasés M, Hervás A, Ramos-Quiroga JA, Bosch R, Bielsa A, Gastaminza X, et al. (May 2008). "Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder". Biological Psychiatry. 63 (10): 935–945. doi:10.1016/j.biopsych.2007.11.004. PMID 18179783. S2CID 15820930.
• Chen ZY, Ieraci A, Teng H, Dall H, Meng CX, Herrera DG, et al. (June 2005). "Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway". The Journal of Neuroscience. 25 (26): 6156–6166. doi:10.1523/JNEUROSCI.1017-05.2005. PMC 1201519. PMID 15987945.
• Pasutto F, Matsumoto T, Mardin CY, Sticht H, Brandstätter JH, Michels-Rautenstrauss K, et al. (October 2009). "Heterozygous NTF4 mutations impairing neurotrophin-4 signaling in patients with primary open-angle glaucoma". American Journal of Human Genetics. 85 (4): 447–456. doi:10.1016/j.ajhg.2009.08.016. PMC 2756554. PMID 19765683.
• Ibáñez CF (July 1996). "Neurotrophin-4: the odd one out in the neurotrophin family". Neurochemical Research. 21 (7): 787–793. doi:10.1007/BF02532301. PMID 8873083. S2CID 10824679.
• Nalbandian A, Pang AL, Rennert OM, Chan WY, Ravindranath N, Djakiew D (October 2005). "A novel function of differentiation revealed by cDNA microarray profiling of p75NTR-regulated gene expression". Differentiation; Research in Biological Diversity. 73 (8): 385–396. doi:10.1111/j.1432-0436.2005.00040.x. PMID 16316409.
• Liu Y, Liu W, Crooks K, Schmidt S, Allingham RR, Hauser MA (March 2010). "No evidence of association of heterozygous NTF4 mutations in patients with primary open-angle glaucoma". American Journal of Human Genetics. 86 (3): 498–9, author reply 500. doi:10.1016/j.ajhg.2009.11.018. PMC 2833375. PMID 20215012.
• Götz R, Schartl M (May 1994). "The conservation of neurotrophic factors during vertebrate evolution" (PDF). Comparative Biochemistry and Physiology. Pharmacology, Toxicology and Endocrinology. 108 (1): 1–10. doi:10.1016/1367-8280(94)90082-5. PMID 8061955.
• Gratacòs M, Escaramís G, Bustamante M, Saus E, Agüera Z, Bayés M, et al. (October 2010). "Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease". Journal of Psychiatric Research. 44 (13): 834–840. doi:10.1016/j.jpsychires.2010.01.009. PMID 20219210.
• Chakrabarti B, Dudbridge F, Kent L, Wheelwright S, Hill-Cawthorne G, Allison C, et al. (June 2009). "Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome". Autism Research. 2 (3): 157–177. doi:10.1002/aur.80. PMID 19598235. S2CID 18239947.
• Mizuno N, Shiba H, Inui T, Takeda K, Kajiya M, Hasegawa N, et al. (November 2008). "Effect of neurotrophin-4/5 on bone/cementum-related protein expressions and DNA synthesis in cultures of human periodontal ligament cells". Journal of Periodontology. 79 (11): 2182–2189. doi:10.1902/jop.2008.070402. PMID 18980528.
• Rao KN, Kaur I, Parikh RS, Mandal AK, Chandrasekhar G, Thomas R, Chakrabarti S (October 2010). "Variations in NTF4, VAV2, and VAV3 genes are not involved with primary open-angle and primary angle-closure glaucomas in an indian population". Investigative Ophthalmology & Visual Science. 51 (10): 4937–4941. doi:10.1167/iovs.10-5553. PMID 20463313.
• Gratacòs M, Costas J, de Cid R, Bayés M, González JR, Baca-García E, et al. (September 2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 150B (6): 808–816. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
• Mercader JM, Saus E, Agüera Z, Bayés M, Boni C, Carreras A, et al. (May 2008). "Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders". Human Molecular Genetics. 17 (9): 1234–1244. doi:10.1093/hmg/ddn013. hdl:10230/16493. PMID 18203754.
• Walz JC, Magalhães PV, Giglio LM, Cunha AB, Stertz L, Fries GR, et al. (April 2009). "Increased serum neurotrophin-4/5 levels in bipolar disorder". Journal of Psychiatric Research. 43 (7): 721–723. doi:10.1016/j.jpsychires.2008.10.005. PMID 19081579. S2CID 7379020.
• Prakash YS, Iyanoye A, Ay B, Mantilla CB, Pabelick CM (September 2006). "Neurotrophin effects on intracellular Ca2+ and force in airway smooth muscle". American Journal of Physiology. Lung Cellular and Molecular Physiology. 291 (3): L447–L456. doi:10.1152/ajplung.00501.2005. PMID 16648236.

External links

• neurotrophin+4 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• neurotrophin+5 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)