Nidogen-2

Nidogen-2, also known as osteonidogen, is a basal lamina protein of the nidogen family. It was the second nidogen to be described after nidogen-1 (entactin). Both play key roles during late embryonic development.^[5] In humans it is encoded by the NID2 gene.^[6][7]

NID2
Identifiers
Aliases	NID2, NID-2, nidogen 2
External IDs	OMIM: 605399; MGI: 1298229; HomoloGene: 40575; GeneCards: NID2; OMA:NID2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.1 Start 52,004,809 bp[1] End 52,069,059 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 A3 Start 19,801,333 bp[2] End 19,861,855 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue stromal cell of endometrium tibia right lobe of thyroid gland left lobe of thyroid gland decidua parietal pleura secondary oocyte tibial nerve right ovary Top expressed in tail of embryo yolk sac genital tubercle dermis endocardial cushion efferent ductule calvaria stroma of bone marrow epiblast abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding collagen binding extracellular matrix structural constituent Cellular component extracellular matrix extracellular region basement membrane extracellular exosome extracellular space plasma membrane collagen-containing extracellular matrix Biological process cell adhesion cell-matrix adhesion extracellular matrix organization basement membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22795 18074 Ensembl ENSG00000087303 ENSMUSG00000021806 UniProt Q14112 O88322 RefSeq (mRNA) NM_007361 NM_008695 RefSeq (protein) NP_031387 NP_032721 Location (UCSC) Chr 14: 52 – 52.07 Mb Chr 14: 19.8 – 19.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000087303 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021806 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Miosge N, Holzhausen S, Zelent C, Sprysch P, Herken R (2002). "Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development". The Histochemical Journal. 33 (9–10): 523–30. doi:10.1023/A:1014995523521. PMID 12005023. S2CID 818451.
6. Kohfeldt E, Sasaki T, Göhring W, Timpl R (Sep 1998). "Nidogen-2: a new basement membrane protein with diverse binding properties". Journal of Molecular Biology. 282 (1): 99–109. doi:10.1006/jmbi.1998.2004. PMID 9733643.
7. "Entrez Gene: NID2 nidogen 2 (osteonidogen)".

Further reading

• Ulazzi L, Sabbioni S, Miotto E, Veronese A, Angusti A, Gafà R, Manfredini S, Farinati F, Sasaki T, Lanza G, Negrini M (2007). "Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer". Molecular Cancer. 6 (1): 17. doi:10.1186/1476-4598-6-17. PMC 1831485. PMID 17328794.
• Nischt R, Schmidt C, Mirancea N, Baranowsky A, Mokkapati S, Smyth N, Woenne EC, Stark HJ, Boukamp P, Breitkreutz D (Mar 2007). "Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture". The Journal of Investigative Dermatology. 127 (3): 545–54. doi:10.1038/sj.jid.5700562. PMID 17008882.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Miosge N, Sasaki T, Timpl R (Nov 2002). "Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice". Matrix Biology. 21 (7): 611–21. doi:10.1016/S0945-053X(02)00070-7. PMID 12475645.
• Tu H, Sasaki T, Snellman A, Göhring W, Pirilä P, Timpl R, Pihlajaniemi T (Jun 2002). "The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin". The Journal of Biological Chemistry. 277 (25): 23092–9. doi:10.1074/jbc.M107583200. PMID 11956183.
• Sasaki T, Göhring W, Mann K, Brakebusch C, Yamada Y, Fässler R, Timpl R (Dec 2001). "Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins". Journal of Molecular Biology. 314 (4): 751–63. doi:10.1006/jmbi.2001.5176. PMID 11733994.
• Sasaki T, Göhring W, Miosge N, Abrams WR, Rosenbloom J, Timpl R (Oct 1999). "Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins". FEBS Letters. 460 (2): 280–4. doi:10.1016/S0014-5793(99)01362-9. PMID 10544250. S2CID 25139630.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.