Núñez (pronounced [ˈnuɲeθ], anglicized as Nunez) is a Spanish surname. The Portuguese (and Old Galician) variant is Nunes. Notable people with the name include:
- Aaron Nunez Cardozo, 1762–1834, Gibraltarian consul for Tunis and Algie
- Alberto Núñez Feijóo (born 1961), Spanish politician
- Casto Méndez Núñez (1824–1869), Spanish military naval officer
- Blasco Núñez Vela (c. 1490–1546), Spanish viceroy of Peru
- Carmen Rosa Núñez Campos (born 1954), Peruvian entrepreneur and politician
- Corazon Nuñez-Malanyaon, Philippine politician
- Devin Nunes (born 1973), member of the United States Congress and chair of the House Intelligence Committee
- Emilio Núñez (1855–1922), Cuban soldier, dentist, and politician
- Emilio Núñez Portuondo (1898–1978), Cuban politician
- Fabian Núñez (born 1966), US-American politician
- José Núñez de Cáceres (1772–1846), Dominican politician and writer
- Marco Antonio Núñez (born 1966), Chilean politician
- Nelly Núñez (1948–2021), Bolivian politician
- Osvaldo Nunez, Canadian politician
- Rafael Núñez (politician), President of Colombia in the 1880s and 1890s
- Samuel B. Nunez, Jr., Louisiana politician
- Yerko Núñez (born 1973), Bolivian politician
- Álvaro Adrián Núñez (born 1973), Uruguayan goalkeeper
- Antonio Núñez (born 1979), Spanish footballer
- Claudio Núñez (born 1975), Chilean footballer
- Darwin Núñez (born 1999), Uruguayan footballer
- Gervasio Núñez (born 1988), Argentine footballer
- Jorge Martín Núñez (born 1978), Paraguayan footballer
- Josep Lluís Núñez (1931–2018), former president of FC Barcelona
- Leonel Núñez (born 1984), Johor Darul Takzim FC player
- Marcelino Núñez (born 2000), Chilean footballer
- Milton Núñez (born 1972), Honduran footballer
- Nicolás Núñez (born 1984), Chilean footballer
- Ramón Núñez (born 1985), Honduran-American footballer
- Rodrigo Núñez (born 1977), Chilean footballer
- Sergio Núñez (born 2000), Uruguayan footballer
- Álvaro Núñez [es], Chilean physicist
- Manuel Núñez Tovar (1872–1928), Venezuelan naturalist, researcher, parasitologist and entomologist
- Samuel Nunez (1668–1744), United States physician and early Jewish settler in Georgia
- Rafael E. Núñez, cognitive scientist
- Marianela Núñez (born 1982), Argentine ballet dancer
- Jacqueline Marie Nuñez, The Person