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Multisystem developmental disorder (MSDD) is a term used by Stanley Greenspan to describe children under age 3 who exhibit signs of impaired communication as in autism, but with strong emotional attachments atypical of autism.[citation needed] It is described in the DC:0-3R manual as an optional diagnosis for children under two years of age.[1][2]
Other uses of the term
Summarize
Perspective
The term multisystem developmental disorder has also been used to describe various developmental disorders. These include:
- Alagille syndrome,[3] an autosomal dominant disorder with a wide range of features and manifestations. Its five most significant features are chronic cholestasis, a condition where bile cannot flow from the liver to the duodenum, occurring in 95% of cases; heart abnormalities (over 90%); butterfly vertebrae; posterior embryotoxon and a distinctive face (prominent forehead, deep-set eyes, and a pointed chin).[4]
- Rubinstein-Taybi syndrome,[5][6] a syndrome characterized by broad thumbs, facial abnormalities, and big toes alongside moderate to severe intellectual disability.[7]
- Williams syndrome,[8][9] a neurodevelopmental disorder characterized by a unique profile of strengths and deficits; most with the condition have mild intellectual disability but have grammatical and lexical abilities above what would be expected from their IQs.[10] They are hypersocial and empathetic, but social isolation is commonly experienced.[11]
- Proteus syndrome,[12] a congenital disorder causing disproportionate growth of skin, bone, and other tissues.[13]
- Asphyxiating thoracic dysplasia,[14] an autosomal recessive skeletal disorder with an estimated prevalence of between 1 in 100,000 and 1 in 130,000 live births.[15]
Symptoms
References
Further reading
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